N-demethylation of cyamemazine via non-classical Polonovski reaction and its conjugation to bovine serum albumin
A modified Polonovski reaction has been employed to obtain the N-demethylated metabolite of the neuroleptic drug cyamemazine. The synthesis involves N-oxide formation, isolation of the corresponding N-oxide, and a FeSO4·7H2O mediated Polonovski reaction to afford the desired monodesmethyl cyamemazine. In a subsequent step the hapten N-demethylcyamemazine-hemiglutarate was synthesized and its conjugated to bovine serum albumin (BSA).
Singh, Gurmit,Koerner, Terry B.,Godefroy, Samuel Benrejeb,Armand, Claude
Synthesis of deuterium-labeled cyamemazine and monodesmethyl cyamemazine
A novel approach is presented for the synthesis of cyamemazine maleate and N-desmethyl cyamemazine maleate using a 10-(amino-2-methylpropyl)phenothiazine derivative. This method was successfully applied to the synthesis of [ 2H6]cyamemazine maleate and N-desmethyl-[ 2H3]cyamemazine maleate.
Bolla, R. Sekhar,Kasi Viswanath
p. 82 - 85
(2014/03/21)
An improved process for the preparation of pure cyamemazine and salts thereof
The present invention provides an improved process for the preparation of cyamemazine of formula-1 or its pharmaceutically acceptable salt thereof, which is substantially free of impurities.
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Page/Page column
(2014/07/09)
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