Facile dimer synthesis for DNA-binding polyamide ligands
(Equation Presented). Pyrrole-imidazole polyamide ligands are highly sequence specific synthetic DNA-binding ligands that bind with high affinity. To counter the synthetic difficulties associated with coupling the electron-rich heterocyclic acids to the electron-deficient nucleophilic imidazole amine, a novel approach is described for synthesis of Fmoc-protected dimers for solid-phase peptide synthesis (SPPS). This method produces the dimers in high yields, is broadly applicable to other heterocyclic-containing polyamides, and results in improved ligand yields and synthesis times.
Provided is a compound having an agonist action on GPR52, which is useful as a prophylactic or therapeutic drug for mental diseases such as schizophrenia and the like, and the like. A compound represented by the formula (I): wherein each symbol is as defi
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Page/Page column 141
(2012/12/14)
Synthesis of Novel Imidazole-Containing DNA Minor Groove Binding Oligopeptides Related to the Antiviral Antibiotic Netropsin
Analysis of the structural and stereochemical requirements for the strict DNA base sequence recognition of (AT)4 and (AT)5 respectively for the oligopeptide minor groove binding agents netropsin and distamycin leads to proposals for the rational structure
Krowicki, Krzysztof,Lown, J. William
p. 3493 - 3501
(2007/10/02)
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