109012-24-0 Usage
Description
1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its imidazole ring structure and carboxylic acid functional group, which contribute to its reactivity and potential applications in the medical field.
Uses
Used in Pharmaceutical Synthesis:
1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID is used as an intermediate in the synthesis of imidazole-containing DNA minor groove binding oligopeptides. These oligopeptides are related to the antiviral antibiotic netropsin, which is effective against a range of viral infections.
Used in Antitumor Applications:
In the field of oncology, 1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID is used to prepare distamycin derivatives. These derivatives exhibit antitumor activities and are being investigated for their potential in treating various types of cancer.
Different applications in different industries:
There are no specific applications mentioned in different industries for 1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID in the provided materials. The uses mentioned are primarily focused on pharmaceutical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 109012-24-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,0,1 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 109012-24:
(8*1)+(7*0)+(6*9)+(5*0)+(4*1)+(3*2)+(2*2)+(1*4)=80
80 % 10 = 0
So 109012-24-0 is a valid CAS Registry Number.
109012-24-0Relevant articles and documents
Facile dimer synthesis for DNA-binding polyamide ligands
Wetzler, Modi,Wemmer, David E.
, p. 3488 - 3490 (2010)
(Equation Presented). Pyrrole-imidazole polyamide ligands are highly sequence specific synthetic DNA-binding ligands that bind with high affinity. To counter the synthetic difficulties associated with coupling the electron-rich heterocyclic acids to the electron-deficient nucleophilic imidazole amine, a novel approach is described for synthesis of Fmoc-protected dimers for solid-phase peptide synthesis (SPPS). This method produces the dimers in high yields, is broadly applicable to other heterocyclic-containing polyamides, and results in improved ligand yields and synthesis times.
Synthesis of Novel Imidazole-Containing DNA Minor Groove Binding Oligopeptides Related to the Antiviral Antibiotic Netropsin
Krowicki, Krzysztof,Lown, J. William
, p. 3493 - 3501 (2007/10/02)
Analysis of the structural and stereochemical requirements for the strict DNA base sequence recognition of (AT)4 and (AT)5 respectively for the oligopeptide minor groove binding agents netropsin and distamycin leads to proposals for the rational structure
