- ALKYLATION OF SOME 6-SUBSTITUTED PURINES UNDER INTERPHASE CATALYSIS CONDITIONS
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The mixture of 9-, 3-, and 7-benzyl-6-substituted purines is formed in almost quantitative yield by the alkylation of 6-benzylamino-, 6-furfurylamino-, 6-methylthio-, and 6-chloropurine with benzyhalides in the biphasic system of the liquid-liquid or liquid-solid type in the presence of interphase catalysts (quarternary ammonium salts, 18-crown-6).The catalytic activity of the quarternary ammonium salts increases with the inrease in the lipophilicity of the cation.Taking the alkylation of 6-benzylaminopurine as an example, the possibility of the application of ''triphasic catalysis'' in the alkylation reaction of purines is indicated.The alkylation of 6-substituted purines with isopropylbromide proceeds regioselectively under the conditions of the interphase catalysis with the formation of the corresponding 9-isopropylpurines.
- Ramzaeva, N. P.,Goncharova, L. N.,Lidak, M. Yu.,Gol'dberg, Yu. Sh.,Shimanskaya, M. V.
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- Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2
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The cell division cycle is controlled by cyclin-dependent kinases (cdk), which consist of a catalytic subunit (cdk1-cdk8) and a regulatory subunit (cyclin A-H). Purine-like inhibitors of cyclin-dependent kinases have recently been found to be of potential
- Otyepka, Michal,Kry?tof, Vladimír,Havlí?ek, Libor,Siglerová, Věra,Strnad, Miroslav,Ko?a, Jaroslav
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