- Synthetic method of chromone derivative
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The invention discloses a chromone derivative synthesis method, which comprises: dissolving a compound RXXR in a solvent, adding [bis(trifluoroacetoxy)iodine]benzene (short for PIFA), carrying out a reaction for 8-15 min, adding a 2-methoxyphenyl acetylen
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Paragraph 0078-0081
(2020/09/16)
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- The synthesis of 3-sulfenylflavones via FeCl3-promoted regioselective cyclization of alkynyl aryl ketones with N-arylthiobenzamides
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A FeCl3-promoted regioselective cyclization of alkynyl aryl ketones with N-arylthiobenzamides had been developed for the synthesis of 3-sulfenylflavones derivatives. Various alkynyl aryl ketones and N-arylthiobenzamides with a number of functional groups were compatible in this reaction to afford the corresponding 3-sulfenylflavones in moderate to good yields. The mechanism was described in detail.
- Shi, Lin-Feng,Zhang, Xing-Guo,Zhang, Xiao-Hong
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supporting information
p. 8617 - 8622
(2016/12/07)
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- Preparation method of 3-arylmercapto flavonoid compound
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The invention discloses a preparation method of a 3-arylmercapto flavonoid compound. The preparation method comprises the following steps: taking 1-(2-methoxyaryl)-3-aryl propargyl ketone as a substrate, adding N-arylthiobenzamide as a sulfur source into the substrate, adding a promoter, and in a reaction solvent, enabling reaction for 20 hours while stirring at the room temperature of 25 DEG C and under atmospheric pressure; after completion of the reaction, filtering a reaction solution to obtain a filtrate; concentrating the filtrate, removing the solvent by using a rotary evaporator to obtain a remainder, performing chromatography on the remainder by using a silica gel column, eluting by using an eluent, and collecting effluent according to an actual gradient; and combining the effluent containing the 3-arylmercapto flavonoid compound, concentrating the combined effluent to remove the solvent, and finally performing vacuum drying to obtain the target product. The preparation method has the advantages of simple preparation process, less pollution, low energy consumption and high yield.
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Paragraph 0032; 0033; 0034; 0038
(2018/02/04)
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- FLAVONOIDS, 40. SYNTHESIS OF 3-ALKYL- AND -ARYLTHIOFLAVANONES AND THEIR TRANSFORMATIONS INTO SULFUR-CONTAINING FLAVONOIDS
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trans-3-Mesyloxyflavanones 1 were converted into cis- and trans-3-(alkylthio)- and -(phenylthio)flavanones 2-4 by nucleophilic substitution reaction with thiols or thiolates.Flavanones 2-4 were useful intermediates in the synthesis of various sulfur-containing derivatives; flavanones, flavones and dihydrochalcones posessing alkyl- or arylthio, -sulfinyl and -sulfonyl group.Oxidation of cis- and trans- isomers of 4 led to completely different products.
- Patonay, Tamas,Patonay-Peli, Erzsebet,Litkei, Gyoergy
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p. 1827 - 1834
(2007/10/02)
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