- PRODRUGS OF CHLOROKYNURENINES
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The present disclosure relates to prodrugs of 7-chlorokynurenic acid. In certain embodiments, the prodrugs include those having the structure of any one of formula (I)-(VIII), wherein R1-R13, monomer 1, monomer 2, and linker are defi
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Paragraph 00121; 00124
(2017/03/28)
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- Tunable P-Chiral Bisdihydrobenzooxaphosphole Ligands for Enantioselective Hydroformylation
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Air-stable and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were employed in rhodium-catalyzed asymmetric hydroformylation of various terminal olefins with excellent conversions (>99%), moderate-to-excellent enantioselectivities (up to 95:5 er), and branched to linear ratios (b:l) of up to 400.
- Tan, Renchang,Zheng, Xin,Qu, Bo,Sader, C. Avery,Fandrick, Keith R.,Senanayake, Chris H.,Zhang, Xumu
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supporting information
p. 3346 - 3349
(2016/07/26)
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- Enantioselective syn and anti homocrotylation of aldehydes: Application to the formal synthesis of spongidepsin
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Whereas crotylboration has been a useful method for synthesis of stereochemically complex products, we have shown that homocrotylboration can be achieved with cyclopropanated crotylation reagents, and that the stereoselectivity of the reaction can be predicted by analogous models. This paper presents a full account of this work, including the first examples of asymmetric anti homocrotylation. The scope of this reaction is demonstrated with highly enantioselective homocrotylation of both aliphatic and aromatic aldehydes, as well as double diastereoselection studies. An application of the synthesis of the marine natural product spongidepsin is presented, as well as streamlined syntheses of homocrotylation reagents.
- Lin, Hongkun,Tian, Leiming,Krauss, Isaac J.
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supporting information
p. 13176 - 13182
(2015/10/28)
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- Diphenylprolinol silyl ether as a catalyst in an asymmetric, catalytic and direct α-benzoyloxylation of aldehydes
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Diphenylprolinol silyl ether was found to promote asymmetric, catalytic and direct α-benzoyloxylation of aldehydes with benzoyl peroxide to afford oxidized products in good yields with excellent enantioselectivity. The Royal Society of Chemistry 2009.
- Gotoh, Hiroaki,Hayashi, Yujiro
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supporting information; scheme or table
p. 3083 - 3085
(2009/12/01)
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- Kinetic resolution of 1,2-diols using nitrogen-tethered bisimidazoline-copper(I) catalyzed benzoylation
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Nitrogen-tethered bisimidazoline (Nb-imidazoline) ligand was utilized in the Cu(I)-catalyzed benzoylation of 1,2-diols. With the assistance of i-Pr2NEt, the reaction of rac-1,2-diols with o-methylbenzoyl chloride was smoothly catalyzed by Nb-imidazoline-CuCl in CH2Cl2 to give the corresponding o-methylbenzoylated secondary alcohols in up to 79% ee.
- Arai, Takayoshi,Mizukami, Tomoe,Mishiro, Asami,Yanagisawa, Akira
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experimental part
p. 995 - 1000
(2009/06/28)
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- Lipase-catalyzed alcoholysis of diol dibenzoates: Selective enzymatic access to the 2-benzoyl ester of 1,2-propanediol and preparation of the enantiomerically pure (R)-1-O-benzoyl-2-methylpropane-1,3-diol
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Enzymatic debenzoylation of 1,2-propanediol dibenzoate with 1-octanol has been studied in organic solvent using lipases from different sources. In general a slow, highly regioselective alcoholysis in diisopropyl ether affords exclusively a monoester benzoylated at the secondary hydroxy group although the reaction proceeds with low enantioselectivity. In the presence of Pseudomonas cepacia lipase absorbed onto celite, a faster reaction allows the preparation of the 2-benzoyl ester of (R)-1,2-propanediol (82% ee) and the enantiomerically pure (R)-1-O-benzoyl-2-methylpropane-1,3-diol (>98% ee).
- Santaniello, Enzo,Casati, Silvana,Ciuffreda, Pierangela,Gamberoni, Luca
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p. 1705 - 1708
(2007/10/03)
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- LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF
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Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. Wherein Q is selected from X-CO-, and -CO-X-; X is selected from-O-, and -NR6-; n is an
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Page/Page column 51-52
(2008/06/13)
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- Pd-catalyzed ScN′ reactions: Stereoselective formation of cyclic carbamates from tert-butyldimethylsilyl carbamates
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Stereo selective formation of cyclic carbamates was achieved by the intramolecular trapping of a tert-butyldimethylsilyloxycarbonyl group with allylic esters upon activation with fluoride and cat. Pd(O). The reactive conformation is proposed to be D. The
- Spears, Glen W.,Nakanishi, Koji,Ohfune, Yasufumi
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p. 5339 - 5342
(2007/10/02)
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