cas 114460-08-1, 1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE | Articles data ｜lookchem

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114460-08-1

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A simple and efficient synthesis of GYKI 52466 and GYKI 52895
The synthesis of 1-(4-aminophenyl)-4-methyl-7,8-methylene-dioxy-5H-2,3-benzodiazepine (GYKI 52466, 1), the prototype of a series of noncompetitive AMPA receptor antagonists, and its 3,4-dihydroderivative (GYKI 52895, 2) is described. The title compounds have been prepared starting from safrole through a quite effective procedure.
Zappala, Maria,Grasso, Silvana,Micale, Nicola,Polimeni, Santina,De Micheli, Carlo
p. 527 - 533
(2007/10/03)

1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine and acid addition salts thereof same
The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. ST
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(2008/06/13)

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Chemical Properties

Boiling Point: 494.5°Cat760mmHg
Flash Point:252.8°C
Density: 1.4g/cm³
Solubility:ethanol: soluble
Vapor Pressure: 6.43E-10mmHg at 25°C
PSA: 68.87000
LogP: 2.62970

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