Gas-phase synthesis of pyrazolo[3,4- b ]pyridin-4-ones
Flash vacuum pyrolysis (FVP) at 500-600 °C of 1-substituted pyrazolylaminomethylene derivatives of Meldrum's acid provides 1-substituted pyrazolo[3,4-b]pyridin-4-ones in high yields. If the 1-substituent is a tert-butyl group, FVP at 750-850 °C causes elimination of 2-methyl-1-propene to give the parent pyrazolo[3,4-b]pyridin-4-one.
Mackay, Martha,Nortcliffe, Andrew,McNab, Hamish,Hulme, Alison N.
COMPOUNDS WITH COPPER- OR ZINC-ACTIVATED TOXICITY AGAINST MICROBIAL INFECTION
Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using same.
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(2022/02/05)
SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME
ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.
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Page/Page column 134
(2016/09/15)
IMIDAZOPYRIDAZINE COMPOUNDS
The present invention relates to the use of novel compounds of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
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Paragraph 0258-0259
(2013/05/09)
IMIDAZOPYRIDAZINE COMPOUNDS
The present invention relates to the use of novel compounds of formula (I): wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
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Page/Page column 59-60
(2013/05/22)
Syntheses of 1-substituted-3-aminopyrazoles
A series of 1-substituted-3-aminopyrazoles were prepared via Chan-Lam coupling reactions, alkylation, and pyrazole ring formation.
Ji, Nan,Meredith, Erik,Liu, Donglei,Adams, Christopher M.,Artman III, Gerald D.,Jendza, Keith C.,Ma, Fupeng,Mainolfi, Nello,Powers, James J.,Zhang, Chun
experimental part
p. 6799 - 6801
(2011/03/18)
NOVEL AMINOPYRIDINE DERIVATIVE HAVING AURORA-A-SELECTIVE INHIBITORY ACTIVITY
The present invention relates to a compound of general formula I: wherein: n1 and n2 are the same or different, and are 0 or 1; R is aryl, heteroaryl, etc.; Re is hydrogen atom or lower alkyl; two groups selected from four groups consisting of (i) either
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Page/Page column 49
(2009/02/10)
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