The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.
-
Page/Page column 301-302
(2020/01/10)
One-pot synthesis of 4,4-difluoro-3-oxo-2-(triphenylphosphoranylidene)-δ-lactones by Reformatsky reaction
In th presence of zinc and a catalytic amount of cuprous chloride, ethyl 4-bromo-4,4-difluoro-3-oxo-2-(triphenylphosphoranylidene)butanoate 1 reacted with carbonyl compounds to give the gem-difluoromethylenated 2-(triphenylphosphoranylidene)-δ-lactones 4
Cyclocondensation of Alkylhydrazines and β-Substituted Acetylenic Esters: Synthesis of 3-Hydroxypyrazoles
Addition of monosubstituted alkylhydrazines to acetylenic esters with either electron-withdrawing or sterically bulky β-substituents afforded 1-alkyl-3-hydroxy-5-substituted-pyrazoles 1 as the major regioisomeric product.By comparison, the classical cyclo
Hamper, Bruce C.,Kurtzweil, Mitchell L.,Beck, James P.
p. 5680 - 5686
(2007/10/02)
Direct Synthesis of β-Keto Methylenetriphenylphosphoranes from Readily Available Phosphonium Salts
-
Hamper, Bruce C.
p. 5558 - 5562
(2007/10/02)
More Articles about upstream products of 116998-21-1