- Synthesis of 3,3-difluoro-DL-alanine and 3,3-difluoro-DL-alanine precursors
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The key intermediate to 3,3-difluoroalanine, 2,2-difluoro-1-ethylthioethylamine hydrobromide (2), was prepared by the Steglich and Weygand procedure. Its conversion to N-benzyloxycarbonyl-2,2-difluoro-1-ethenylethylamine (5) followed by oxidation and subsequent deprotection of the amine afforded the 3,3-difluoroalanine.
- D'Orchymont
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p. 961 - 963
(2007/10/02)
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