2,2,2-Trifluoroethyl Chlorooxoacetate-Universal Reagent for One-Pot Parallel Synthesis of N1-Aryl-N2-alkyl-Substituted Oxamides
A one-pot parallel synthesis of N1-aryl-N2-alkyl-substituted oxamides with 2,2,2-trifluoroethyl chlorooxoacetate was developed. The synthesis of a library of 45 oxamides revealed higher efficiency of this reagent over the known ethyl chlorooxoacetate. The reagent was successfully used to prepare the known oxamide-containing HIV entry inhibitors.
Bogolubsky, Andrey V.,Moroz, Yurii S.,Mykhailiuk, Pavel K.,Pipko, Sergey E.,Zhemera, Anton V.,Konovets, Anzhelika I.,Stepaniuk, Olena O.,Myronchuk, Inna S.,Dmytriv, Yurii V.,Doroschuk, Roman A.,Zaporozhets, Olga A.,Tolmachev, Andrey
Synthesis and characterization of new mono-, bis-, and tris-oxamato proligands
This communication presents the synthesis and the characterization of new organic molecules bearing up to three N-phenyl-oxalamic acid ethyl esters. The syntheses are based on Sonogashira-type cross-coupling reactions with preformed oxalamic ester interme
Stroh, Christophe,Stuparu, Alexandrina
supporting information; experimental part
p. 5157 - 5159
(2010/11/16)
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