1178671-79-8Relevant articles and documents
2,2,2-Trifluoroethyl Chlorooxoacetate-Universal Reagent for One-Pot Parallel Synthesis of N1-Aryl-N2-alkyl-Substituted Oxamides
Bogolubsky, Andrey V.,Moroz, Yurii S.,Mykhailiuk, Pavel K.,Pipko, Sergey E.,Zhemera, Anton V.,Konovets, Anzhelika I.,Stepaniuk, Olena O.,Myronchuk, Inna S.,Dmytriv, Yurii V.,Doroschuk, Roman A.,Zaporozhets, Olga A.,Tolmachev, Andrey
, p. 615 - 622 (2015)
A one-pot parallel synthesis of N1-aryl-N2-alkyl-substituted oxamides with 2,2,2-trifluoroethyl chlorooxoacetate was developed. The synthesis of a library of 45 oxamides revealed higher efficiency of this reagent over the known ethyl chlorooxoacetate. The reagent was successfully used to prepare the known oxamide-containing HIV entry inhibitors.
