- Direct observation of adsorption kinetics on clays by cation-π interaction-triggered aggregation luminescence
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Luminescence quenching of organic molecules in an aggregation state has become a long-standing challenge for further imaging applications. Inspired by recent research on cation-π interaction triggered luminescence, we designed and synthesized an organic cation, E-4-formyl-styryl-pyridinium salt (FSPH), with strong fluorescent emission in the aggregation state. The formation of the FSPH dimer replaces weaker π-π interactions with stronger cation-π interactions to trigger the aggregation luminescence. The excellent optical performances of FSPH in the aggregation state show promise in elucidating the adsorption kinetics of clays because the aggregation of adsorbates during clay adsorption is inevitable. Expectedly, the complete adsorption kinetics of FSPH on clays was visualized by virtue of an in situ fluorescence imaging technique. The subsequent fluorescence intensity quantification revealed that the adsorption kinetics of FPSH on clays could be divided into three stages: molecular aggregation at the edge, formation of a block layer, and molecular invasion from the edge to the center. The discovery of the formation of a block layer not only identifies a previously unknown source of the lower adsorption capacity with larger particle sizes of clays, but also inspires the great passion of scientists to study the adsorption kinetics of other adsorbents by employing cation-π interaction-triggered aggregation luminescence.
- Zhong, Jinpan,Cui, Xingyu,Guan, Weijiang,Lu, Chao
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- X-ray structures of precursors of styrylpyridine-derivatives used to obtain 4-((E)-2-(pyridin-2-yl)vinyl)benzamido-TEMPO: Synthesis and characterization
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The synthesis and characterization of the precursor isomers trans-4-(2-(pyridin-2-yl)vinylbenzaldehyde (I), trans-4-(2-(pyridin-4-yl)vinylbenzaldehyde (II), trans-4-(2-(pyridin-2-yl)vinylbenzoic acid (III) and (E)-4-(2-(pydridin-4-yl)vinylbenzoic acid (IV
- Soriano-Moro, Guillermo,Percino, María Judith,Sánchez, Ana Laura,Chapela, Víctor Manuel,Cerón, Margarita,Castro, María Eugenia
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- Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation
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Aggregation of α-synuclein (α-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the native, monomeric protein with suitable molecule ligands. We have designed and synthesized a series of sheet-like conjugated compounds which possess different skeletons and various heteroatoms in the two blocks located at both ends of linker, which have good π-electron delocalization and high ability of hydrogen-bond formation. They have shown anti-aggregation activities in vitro towards α-Syn with IC50 down to 1.09 μM. The molecule is found binding in parallel to the NACore within NAC domain of α-Syn, interfering aggregation of NAC region within different α-Syn monomer, and further inhibiting or slowing down the formation of α-Syn oligomer nuclei at lag phase. The potential inhibitor obtained by our strategy is considered to be highly efficient to inhibit α-Syn aggregation.
- Liu, Hao,Chen, Li,Zhou, Fei,Zhang, Yun-Xiao,Xu, Ji,Xu, Meng,Bai, Su-Ping
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supporting information
p. 3089 - 3096
(2019/06/14)
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- Green synthesis and photophysical properties of novel 1H-imidazo[4,5-f][1,10]phenanthroline derivatives with blue/cyan two-photon excited fluorescence
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A simple, rapid, and highly efficient method has been developed for the synthesis of a series of novel 1H-imidazo[4,5-f][1,10]phenanthroline derivatives (1BN, 2Py, 3BI, 4BT, and 5MOBI) via a three–component, one–pot reaction under solvent–free conditions.
- Pan, Yu-Lu,Cai, Zhi-Bin,Bai, Li,Ma, Fei-Fei,Li, Sheng-Li,Tian, Yu-Peng
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p. 2886 - 2893
(2017/04/26)
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- A-pi-A' compounds, and preparation method and application thereof
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The invention discloses A-pi-A' compounds, and a preparation method and an application thereof. The structure of the compounds is represented by formula (I) or formula (II), the compounds of the formula (I) are chemically called as 2-(1E)-2-[4-(1H-imidazo
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Paragraph 0023; 0024
(2017/08/31)
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- Synthesis, chiroptical and SHG properties of polarizable push-pull dyes built on π-extended binaphthyls
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We report on new enantiopure binaphthyl derivatives in which electron-donating and electron-withdrawing substituents are placed in direct conjugation, to create active push-pull dyes for NLO applications. The dyes, unprecedentedly, extend their π-bridge from the 3,3′ positions of the binaphthyl units, and incorporate as acceptors pyridine units, possessing a coordinating nitrogen atom useful for further supramolecular polarization of the chiral dyes. The π-bridge is constructed by the sequential attachment of phenylenevinylene units to the enantiopure binaphthyl derivatives through Horner-Wadsworth-Emmons olefination, which proceed with high stereoselectivity, affording stereodefined chiral dyes. The polarization of the terminal pyridine units by means of labile complexation with Pd2+ ions has been demonstrated using both optical and chiroptical methods. The polarization by protonation can be made reversible in solution and solid state by exposure to ammonia vapors, as shown by absorption and emission spectroscopies. NLO properties, as determined by EFISH generation measurements in solution, are significant for the bisprotonated species when compared to previously reported binaphthyl substrates. TDDFT calculations show that the hyperpolarizability tensor contribution is responsible for enhancing SHG values upon protonation up to one order of magnitude, highlighting the potential of such ortho related, axially-chiral push-pull dyes for functional NLO applications.
- Coluccini, Carmine,Caricato, Marco,Cariati, Elena,Righetto, Stefania,Forni, Alessandra,Pasini, Dario
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p. 21495 - 21503
(2015/03/30)
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- Novel compounds useful for modulating abnormal cell proliferation
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There is described compounds of Formulae I, II, III, IV and V. The compounds of Formulae I, II, III, IV and/or V are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.
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Page/Page column 7
(2008/06/13)
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- Benzimidazole compounds as bradykinin antagonists
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PCT No. PCT/JP95/01478 Sec. 371 Date Feb. 3, 1997 Sec. 102(e) Date Feb. 3, 1997 PCT Filed Jul. 25, 1995 PCT Pub. No. WO96/04251 PCT Pub. Date Feb. 15, 1996This invention relates to a heterocyclic compound of the formula: wherein a group of the formula: is a group of the formula: etc., X is O, S or N-R5, R1 is lower alkyl, etc., R5 is hydrogen, lower alkyl, etc., R2 is hydrogen, halogen, lower alkyl, etc., R3 is halogen, lower alkyl, etc., R4 is amino optionally having suitable substituent(s), and A is lower alkylene, and a salt thereof, to processes for preparation thereof, and to a pharmaceutical composition comprising the same for the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.
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- Quantitative Formation of a Paracyclophane Derivative via Topochemical Photoreaction of a Crystal Complex of Ethyl and Propyl α-Cyano-4-cinnamates
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The complex with the composition ranging from 6:4 to 2:8 of ethyl α-cyano-4-cinnamate (1) and propyl α-cyano-4-2-(4-pyridyl)ethenyl)cinnamate (2) photodimerized quantitatively into the three types of tricyclic dimer crystal, indicat
- Hasegawa, Masaki,Maekawa, Yashunari,Kato, Satoshi,Saigo, Kazuhiko
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p. 907 - 910
(2007/10/02)
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