- DENTRITIC POLYMERS, CROSSLINKED GELS, AND THEIR USES IN ORTHOPEDIC APPLICATIONS
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The present invention provides compositions, kits, and methods for repairing cartilaginous tissue. Certain methods of the invention utilize dendritic macromolecules formed by treating a dendritic compound with light or a linking compound. In certain instances, the dendritic compounds have a lysine, cysteine, isocysteine residue or other nucleophilic group attached to their peripheries. Addition of a compound containing two or more electrophilic groups, such as aldehydes, activated esters, or acrylates, to the lysine-capped, cysteine-capped, or isocysteine-capped dendrimers produces a polymeric compound that can repair a cartilage defect.
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Page/Page column 271-272
(2010/10/20)
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- Effects of steric bulk and stereochemistry on the rates of?diketopiperazine formation from N-aminoacyl-2,2-dimethylthiazolidine-4-carboxamides (Dmt dipeptide amides)-a model for a new prodrug linker system
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A peptide-like self-immolative molecular clip is required for release of active drugs from prodrugs by endopeptidases. Upon cleavage from the carrier, this clip must collapse and release the drug rapidly. A series of aminoacyl-5,5-dimethylthiaproline (Aaa
- Suaifan, Ghadeer A.R.Y.,Mahon, Mary F.,Arafat, Tawfiq,Threadgill, Michael D.
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p. 11245 - 11266
(2007/10/03)
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- Dendritic macromers as in situ polymerizing biomaterials for securing cataract incisions
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Dendritic macromers are attractive macromolecules for hydrogel formation since high cross-linking densities at low polymer concentration can be obtained, varied physical properties can be observed based on the macromer structure, and low viscous aqueous s
- Wathier, Michel,Jung, Pil J.,Carnahan, Michael A.,Kim, Terry,Grinstaff, Mark W.
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p. 12744 - 12745
(2007/10/03)
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- Boc-L-Dmt-OH as a Fully N,S-Blocked Cysteine Derivative for Peptide Synthesis by Prior Thiol Capture. Facile Conversion of N-Terminal Boc-L-Dmt-Peptides to H-Cys(Scm)-Peptides
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An efficient, convenient preparation of N-L-(tert-butyloxycarbonyl)-2,2-dimethylthiazolidine-4-carboxylic acid (Boc-Dmt-OH) is reported.The following rate constants assess the coupling efficiency and racemization risk of Boc-L-Dmt-OC6F5 in THF at 22 deg C.With H-Val-OMe, kcouple = 3.2*10-2M-1s-1, and with Et3N, krac -8M-1s-1.Conversions of derivatives of the sequence Cys-Gly-Gly-Ala to the corresponding Scm-functionalized (Scm = methoxycarbonylsulfenyl, MeOCOS) cysteine peptides illustrated transformation of -Dmt- to -Cys(Scm)- with or without prior Boc cleavage.A palladium black catalyzed hydrogenolysis of a benzyl ester in the presence of the thiazolidine is reported in the solution-phase synthesis of the tripeptide Boc-Dmt-Leu-Ala-OBzl.The functionalized octapeptide 58-51 of basic pancreatic trypsin inhibitor, H-Cys(Scm)-Met-Arg-Thr-Cys(Dnp)-Gly-Gly-Ala-OH, was prepared by a 4 + 4 thiol capture and acyl-transfer strategy to demonstrate the applicability of the thiazolidine to this method.
- Kemp, D. S.,Carey, Robert I.
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p. 3640 - 3646
(2007/10/02)
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