- A refining method of Cefprozil (by machine translation)
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The invention relates to a kind of Cefprozil refining method, including Cefprozil crude synthesis and Cefprozil refining, wherein the refining comprises: 1) will Cefprozil crude product in adding ethanol, stirring, dilute hydrochloric acid aqueous solution to adjust the pH to 2.0 - 2.2, stirring, dissolving crude product, filtering, to obtain the Cefprozil salt of the crude solution; 2) the above-mentioned solution adds by drops to 4% sodium bicarbonate solution, adjusting the pH to 4.6 - 5.0, cooling, thermal insulation mixing, filtering, washing, and a ground line, to get the solid; 3) step 2) the resulting solid dissolved in water, adding activated carbon, heating to 30 - 35 °C, fully stirring, after filtering the filtrate, the filtrate is cooled to 0 - 5 °C, added to the mixed solvent, crystallization, control the temperature and the stirring speed brilliantly 1.5 h, filtering, washing, and a ground line, vacuum drying, spore propylene pure product. The present invention provides a refined method has the simple conditions, cis-isomer content high, high purity and the like. (by machine translation)
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Paragraph 0020; 0036; 0037
(2018/05/30)
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- Synthetic method of cefprozil
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The invention relates to a synthetic method of cefprozil. The synthetic method comprises the following steps: iodination reaction and Wittig reaction are performed on 7-ACA as a starting material after silylation protection, and a compound 2 is generated; a compound 1, namely, the target product cefprozil is generated from the compound 2 and methyl D-(-)-4-hydroxy-phenylglycinate under catalysis of AlMe3. The conversion rate is high, the process is simple, the cis-isomer content is high, and the synthetic method is suitable for large-scale industrial production.
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Paragraph 0020; 0029; 0034; 0040; 0046; 0052
(2018/05/30)
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- Commercial synthesis of cefprozil: Development and control of process impurity
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A process impurity, ethoxycarbonylcefprozil (9), formed in the synthesis of cefprozil (1) was controlled with addition of a catalytic amount of methanesulfonic acid.
- Rai, Bishwa Prakash,Tewari, Neera,Nizar, Hashim,Prasad, Mohan,Joseph, Sony
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p. 662 - 664
(2014/06/09)
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- PROCESSES FOR THE PREPARATION OF CEPHALOSPORIN DERIVATIVES
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Provided is a process for preparing a compound of formula 1 or its salt. The process includes reacting a compound of formula 4 with acetaldehyde in a mixed solvent including water, isopropanol, and methylenechloride in a volume ratio of 1:3-6:11-14 in the
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Page/Page column 8
(2008/06/13)
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- PROCESSES FOR THE PREPARATION OF CEPHEM DERIVATIVES
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Provided is a process for preparing a compound of formula 1 or its salt, which includes reacting a compound of formula 2 with a compound of formula 3 in the presence of a base.
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Page/Page column 18; 19
(2008/06/13)
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- PROCESS FOR THE PREPARATION OF 7-AMINO (p-HYDROXYPHENYLGLYCYL) CEPHEM COMPOUNDS
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The invention relates to pure 7- amino (p-hydroxyphenylglycyl) cephem compounds. The invention also relates to processes for the preparation of pure 7- amino (p-hydroxyphenylglycyl) cephem compounds and pharmaceutical compositions that include the pure 7- amino (p-hydroxyphenylglycyl) cephem compounds.
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