121412-77-9

Basic information

• Product Name: CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI)
• Synonyms: CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI);Cefprozil (Z)-Isomer (200 mg);Cefprozil (Z)-IsoMer
• CAS NO: 121412-77-9
• Molecular Formula: C₁₈H₁₉N₃O₅S
• Molecular Weight: 389.42556
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 121412-77-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 218-220° (dec)
• Boiling Point: 803.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• PKA: 2.92±0.50(Predicted)
• CAS DataBase Reference: CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI)(CAS DataBase Reference)
• NIST Chemistry Reference: CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI)(121412-77-9)
• EPA Substance Registry System: CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI)(121412-77-9)

Safety Data

• Hazardous Substances Data: 121412-77-9(Hazardous Substances Data)

Usage

Description

CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI) is a stereoisomer of Cefprozil (C243910), a semisynthetic oral cephalosporin antibiotic. It is part of a mixture with an approximate ratio of 90:10 Z/E isomers. This specific isomer possesses antibacterial properties and is utilized in the treatment of various bacterial infections.

Uses

Used in Pharmaceutical Industry:
CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI) is used as an antibacterial agent for treating a range of bacterial infections. Its effectiveness lies in its ability to target and disrupt the bacterial cell wall synthesis, thereby inhibiting the growth and reproduction of the bacteria, leading to the clearance of the infection.

Upstream product

• 106447-44-3 cis-7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid 
• 78858-51-2 C₁₆H₁₉NO₇ 
• 37763-23-8 D-2-p-hydroxyphenylglycine methyl ester 
• 685836-16-2 C₁₆H₂₈N₂O₃SSi₂ 
• 120709-09-3 (7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid 

Relevant articles and documents

A refining method of Cefprozil (by machine translation)

The invention relates to a kind of Cefprozil refining method, including Cefprozil crude synthesis and Cefprozil refining, wherein the refining comprises: 1) will Cefprozil crude product in adding ethanol, stirring, dilute hydrochloric acid aqueous solution to adjust the pH to 2.0 - 2.2, stirring, dissolving crude product, filtering, to obtain the Cefprozil salt of the crude solution; 2) the above-mentioned solution adds by drops to 4% sodium bicarbonate solution, adjusting the pH to 4.6 - 5.0, cooling, thermal insulation mixing, filtering, washing, and a ground line, to get the solid; 3) step 2) the resulting solid dissolved in water, adding activated carbon, heating to 30 - 35 °C, fully stirring, after filtering the filtrate, the filtrate is cooled to 0 - 5 °C, added to the mixed solvent, crystallization, control the temperature and the stirring speed brilliantly 1.5 h, filtering, washing, and a ground line, vacuum drying, spore propylene pure product. The present invention provides a refined method has the simple conditions, cis-isomer content high, high purity and the like. (by machine translation)

Commercial synthesis of cefprozil: Development and control of process impurity

A process impurity, ethoxycarbonylcefprozil (9), formed in the synthesis of cefprozil (1) was controlled with addition of a catalytic amount of methanesulfonic acid.

PROCESSES FOR THE PREPARATION OF CEPHEM DERIVATIVES

Provided is a process for preparing a compound of formula 1 or its salt, which includes reacting a compound of formula 2 with a compound of formula 3 in the presence of a base.