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Brisoral

Base Information Edit
  • Chemical Name:Brisoral
  • CAS No.:121412-77-9
  • Molecular Formula:C18H19N3O5S
  • Molecular Weight:389.432
  • Hs Code.:2941906000
  • UNII:W5T767OA4G
  • DSSTox Substance ID:DTXSID50873544
  • Wikidata:Q27292357
  • NCI Thesaurus Code:C80091
  • Mol file:121412-77-9.mol
Brisoral

Synonyms:7-(2-amino-2-(4-hydroxyphenyl)acetamido)-3-(propenyl)-3-cephem-4-carboxylic acid monohydrate;7-(2-amino-2-(p-hydroxyphenyl)acetamido)-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid;Arzimol;BMY 28100;BMY-28100;Brisoral;cefprozil;cefprozil monohydrate;Cefzil;Procef

Suppliers and Price of Brisoral
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Cefprozil (Z)-Isomer
  • 25mg
  • $ 265.00
  • Sigma-Aldrich
  • Cefprozil (Z)-Isomer United States Pharmacopeia (USP) Reference Standard
  • 200 mg
  • $ 373.00
Total 4 raw suppliers
Chemical Property of Brisoral Edit
Chemical Property:
  • Melting Point:218-220° (dec) 
  • Boiling Point:803.1±65.0 °C(Predicted) 
  • PKA:2.92±0.50(Predicted) 
  • PSA:161.75000 
  • Density:1.53±0.1 g/cm3(Predicted) 
  • LogP:2.18520 
  • XLogP3:-1.4
  • Hydrogen Bond Donor Count:4
  • Hydrogen Bond Acceptor Count:7
  • Rotatable Bond Count:5
  • Exact Mass:389.10454189
  • Heavy Atom Count:27
  • Complexity:699
Purity/Quality:

95% *data from raw suppliers

Cefprozil (Z)-Isomer *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC=CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O
  • Isomeric SMILES:C/C=C\C1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)SC1)C(=O)O
  • Uses Cefprozil (Z)-Isomer is a stereoisomer of Cefprozil (C243910), a semisynthetic oral cephalosporin consisting of approx. 90:10 Z/E isomeric mixture. Antibacterial.
Technology Process of Brisoral

There total 5 articles about Brisoral which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
cis-7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid; With trimethylaluminum; In hexane; dichloromethane; at 20 ℃; for 2h;
D-2-p-hydroxyphenylglycine methyl ester; In hexane; dichloromethane; at 35 ℃; for 2h;
Guidance literature:
C16H19NO7; C16H28N2O3SSi2; at -45 - -30 ℃; for 1h; Large scale;
With hydrogenchloride; In water; at 0 - 5 ℃; for 0.25h; Large scale;
DOI:10.1021/op5000545
Guidance literature:
(7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid; ((R)-(2-ethoxycarbonyl-1-methyl-vinylamino)-(4-hydroxyphenyl)-acetyloxy)-(triphenyl)phosphonium chloride; With triethylamine; In dichloromethane; water; at -40 - 0 ℃; for 3h;
With hydrogenchloride; In dichloromethane; water; for 1h;
With sodium hydroxide; In dichloromethane; water; at 0 ℃; for 2h; pH=3.2;
Refernces Edit
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