CEFPROZIL (E)-ISOMER (50 MG)G0D341872UG/MG(AI)

Base Information

• Chemical Name: CEFPROZIL (E)-ISOMER (50 MG)G0D341872UG/MG(AI)
• CAS No.: 92676-86-3
• Molecular Formula: C18H19N3O5S
• Molecular Weight: 389.432
• Hs Code.: 2941906000
• Mol file: 92676-86-3.mol

Synonyms:E-cefprozil;7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(E)-propen-1-yl]-3-cephem-4-carboxylic acid;((E)-4-oxo-thiazolidin-2-ylidene)-acetic acid methyl ester;Acetic acid,(4-oxo-2-thiazolidinylidene)-,methyl ester,(E);(7R,8R)-7-[(R)-2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(E)-propen-1-yl]-3-cephem-4-carboxylic acid;trans-Cefprozil;E-Carbomethoxymethylenthiazolidin-4-on;

Chemical Property of CEFPROZIL (E)-ISOMER (50 MG)G0D341872UG/MG(AI)

Chemical Property:

• Melting Point: 230° (dec)
• Boiling Point: 803.1°Cat760mmHg
• PKA: 2.92±0.50(Predicted)
• Flash Point: 439.5°C
• PSA: 170.98000
• Density: g/cm³
• LogP: 2.12090

Purity/Quality:

97% ^*data from raw suppliers

Cefprozil (E)-Isomer ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Cefprozil (E)-Isomer is a stereoisomer of Cefprozil (C243910), a semisynthetic oral cephalosporin consisting of approx. 90:10 Z/E isomeric mixture. Antibacterial.

Technology Process of CEFPROZIL (E)-ISOMER (50 MG)G0D341872UG/MG(AI)

There total 2 articles about CEFPROZIL (E)-ISOMER (50 MG)G0D341872UG/MG(AI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid (120709-09-3) + ((R)-(2-ethoxycarbonyl-1-methyl-vinylamino)-(4-hydroxyphenyl)-acetyloxy)-(triphenyl)phosphonium chloride → cefprozil (121412-77-9) + E-cefprozil (92676-86-3)

Guidance literature:

(7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid; ((R)-(2-ethoxycarbonyl-1-methyl-vinylamino)-(4-hydroxyphenyl)-acetyloxy)-(triphenyl)phosphonium chloride; With triethylamine; In dichloromethane; water; at -40 - 0 ℃; for 3h;

With hydrogenchloride; In dichloromethane; water; for 1h;

With sodium hydroxide; In dichloromethane; water; at 0 ℃; for 2h; pH=3.2;

Reference yield:

(7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid (120709-09-3) → cefprozil (121412-77-9) + E-cefprozil (92676-86-3)

Guidance literature:

potassium (R)-(2-ethoxycarbonyl-1-methyl-vinylamino)-(4-hydroxyphenyl)-acetate; With pyridine; pivaloyl chloride; In DMF (N,N-dimethyl-formamide); dichloromethane; at -30 ℃; for 2h;

(7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid; With triethylamine; In DMF (N,N-dimethyl-formamide); dichloromethane; water; at -40 - 0 ℃; for 3h;

upstream raw materials:

(7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid

Refernces

• 1、 -. "PROCESSES FOR THE PREPARATION OF CEPHALOSPORIN DERIVATIVES". Page/Page column 8. . Retrieved 2008/06/13.