Interplay between the ribosomal tunnel, nascent chain, and macrolides influences drug inhibition
Accumulating evidence suggests that, during translation, nascent chains can form specific interactions with ribosomal exit tunnel to regulate translation and promote initial folding events. The clinically important macrolide antibiotics bind within the ex
Starosta, Agata L.,Karpenko, Viktoriya V.,Shishkina, Anna V.,Mikolajka, Aleksandra,Sumbatyan, Natalia V.,Schluenzen, Frank,Korshunova, Galina A.,Bogdanov, Alexey A.,Wilson, Daniel N.
Amino acid and peptide derivatives of the tylosin family of macrolide antibiotics modified by aldehyde function
Fourteen new functionally active amino acid and peptide derivatives of the antibiotics tylosin, desmycosin, and 5-O-mycaminosyltylonolide were synthesized in order to study the interaction of the growing polypeptide chain with the ribosomal tunnel. The co