- 1, 4, 5, 6-tetrahydro-pyrimidine derivative synthesis method
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The invention discloses a novel method for synthesizing a 1,4,5,6-tetrahydropyrimidine derivative. The derivative is prepared through reaction between 2-aryl-substituted nitrile and 1,3-diaminopropane with copper cinnamate as a catalyst. The novel method has the advantages that the synthesis technology is simple and does not have strict requirements on reaction conditions, and the catalyst is cheap and can be reutilized, thereby facilitating actual production; the yield can reach 60%-90%.
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Paragraph 0038-0040
(2017/01/26)
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- Microwave-assisted cascade cycloaddition for C-N bond formation: An approach to the construction of 1,4,5,6-tetrahydropyrimidine and 2-imidazoline derivatives
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An efficient strategy for the synthesis of various 1,4,5,6- tetrahydropyrimidine and 2-imidazoline derivatives has been reported. The reactions proceeded from nitriles with ethylenediamine or 1,3-diaminopropane via cascade cycloaddition in the presence of CuL2 (L = 2-hydroxy-2-phenylacetate) to afford the corresponding 1,4,5,6- tetrahydropyrimidine or 2-imidazoline derivatives under reflux conditions or microwave irradiation in excellent yields.
- An, Shujuan,Yin, Bing,Liu, Ping,Li, Xiangnan,Li, Chen,Li, Jianli,Shi, Zhen
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p. 2525 - 2532
(2013/09/24)
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- A green and selective synthesis of 2-aryloxazines and 2- aryltetrahydropyrimidines
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An efficient method for the selective synthesis of 2-substituted oxazines and tetrahydropyrimidines by the reaction of arylnitriles with 3-amino-1-propanol and 1,3-diaminopropane in the presence of montmorillonite K-10 and KSF as inexpensive, environmenta
- Mohammadpoor-Baltork, Iraj,Moghadam, Majid,Tangestaninejad, Shahram,Mirkhani, Valiollah,Eskandari, Zohre
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experimental part
p. 479 - 483
(2011/05/14)
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- H3PW12O40: An efficient and recyclable heterogeneous catalyst for the selective synthesis of 2-Aryl-5,6-dihydro-4H-1,3- oxazines and 2-Aryl-1,4,5,6-tetrahydropyrimidines
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An environmentally friendly and highly efficient procedure has been developed for the selective synthesis of 2-aryl-5,6-dihydro-4H-1,3-oxazines and 2-aryl-1,4,5,6-tetrahydropyrimidines by cyclocondensation of arylnitriles with 3-amino-1-propanol and 1,3-diaminopropane in the presence of catalytic amounts of H3PW12O40 under thermal conditions and MW irradiation. Under the same reaction conditions, dicyanobenzenes are transformed to their corresponding mono-oxazines and monotetrahydropyrimidines with excellent chemoselectivity. These reactions are simple and clean, giving the products in high yields and high purity. The catalyst can be easily recovered after the reaction and reused efficiently in subsequent runs.
- Mohammadpoor-Baltork, Iraj,Moghadam, Majid,Tangestaninejad, Shahram,Mirkhani, Valiollah,Eskandari, Zohre
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experimental part
p. 461 - 469
(2010/10/01)
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