- The Mechanism of Deamination of Methoxy Substituted Tritylammonium Ions in Methanolic Aqueous Acid
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In methanolic aqueous acid, methoxy-substituted tritylammonium ions undergo heterolysis to give an equilibrium mixture of the substituted trityl cation, the corresponding alcohol (and methyl ether), and the ammonium cation via an SN1 mechanism; the detection of a reaction channel first order in hydronium ions may implicate substituted trityl cation-ammonia (ion-molecule) pairs as reactive intermediates.
- Bleasdale, Christine,Golding, Bernard T.,Lee, Won Heui,Maskill, H.,Riseborough, Jane,Smits, Elly
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- Antisense modulation of resistin expression
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Antisense compounds, compositions and methods are provided for modulating the expression of resistin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding resistin. Methods of using these compounds for modulation of resistin expression and for treatment of diseases associated with expression of resistin are provided.
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Page/Page column 19
(2010/02/05)
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- Antisense modulation of G protein-coupled receptor 12 expression
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Antisense compounds, compositions and methods are provided for modulating the expression of G protein-coupled receptor 12. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G protein-coupled receptor 12. Methods of using these compounds for modulation of G protein-coupled receptor 12 expression and for treatment of diseases associated with expression of G protein-coupled receptor 12 are provided.
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Page/Page column 19-20
(2010/11/30)
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- Antisense modulation of PTPRA expression
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Antisense compounds, compositions and methods are provided for modulating the expression of PTPRA. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTPRA. Methods of using these compounds for modulation of PTPRA expression and for treatment of diseases associated with expression of PTPRA are provided.
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Page/Page column 19
(2008/06/13)
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- Antisense modulation of phosphotyrosyl phosphatase activator expression
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Antisense compounds, compositions and methods are provided for modulating the expression of phosphotyrosyl phosphatase activator. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding phosphotyrosyl phosphatase activator. Methods of using these compounds for modulation of phosphotyrosyl phosphatase activator expression and for treatment of diseases associated with expression of phosphotyrosyl phosphatase activator are provided.
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Page/Page column 19
(2008/06/13)
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- Antisense modulation of Ran GTPase activating protein 1 expression
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Antisense compounds, compositions and methods are provided for modulating the expression of Ran GTPase activating protein 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Ran GTPase activating protein 1. Methods of using these compounds for modulation of Ran GTPase activating protein 1 expression and for treatment of diseases associated with expression of Ran GTPase activating protein 1 are provided.
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Page/Page column 19
(2010/02/05)
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- Antisense modulation of KIAA1531 protein expression
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Antisense compounds, compositions and methods are provided for modulating the expression of KIAA1531 protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding KIAA1531 protein. Methods of using these compounds for modulation of KIAA1531 protein expression and for treatment of diseases associated with expression of KIAA1531 protein are provided.
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Page/Page column 19
(2010/02/05)
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- Antisense modulation of G protein-coupled receptor 6 expression
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Antisense compounds, compositions and methods are provided for modulating the expression of G protein-coupled receptor 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G protein-coupled receptor 6. Methods of using these compounds for modulation of G protein-coupled receptor 6 expression and for treatment of diseases associated with expression of G protein-coupled receptor 6 are provided.
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Page/Page column 19
(2010/02/05)
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- Antisense modulation of PPP2R1A expression
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Antisense compounds, compositions and methods are provided for modulating the expression of PPP2R1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PPP2R1A. Methods of using these compounds for modulation of PPP2R1A expression and for treatment of diseases associated with expression of PPP2R1A are provided.
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Page/Page column 19
(2010/02/05)
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- Antisense modulation of requiem expression
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Antisense compounds, compositions and methods are provided for modulating the expression of requiem. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding requiem. Methods of using these compounds for modulation of requiem expression and for treatment of diseases associated with expression of requiem are provided.
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Page/Page column 19
(2010/02/05)
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- Antisense modulation of LAR expression
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Antisense compounds, compositions and methods are provided for modulating the expression of LAR. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding LAR. Methods of using these compounds for modulation of LAR expression and for treatment of diseases associated with expression of LAR are provided.
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Page/Page column 19
(2010/02/05)
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- Antisense modulation of hepatoma-derived growth factor expression
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Antisense compounds, compositions and methods are provided for modulating the expression of hepatoma-derived growth factor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding hepatoma-derived growth factor. Methods of using these compounds for modulation of hepatoma-derived growth factor expression and for treatment of diseases associated with expression of hepatoma-derived growth factor are provided.
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Page/Page column 19
(2010/11/30)
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- Protection of nucleosides
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A process of manufacturing protected nucleosides comprises reacting a nucleoside with a protecting reagent in the presence of a regioselective activator to produce a regioselectively protected nucleoside. In some embodiments of the inventive method, an op
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- Phosphatidylinositol-4-phosphate 5-kinase, type II beta inhibitors for inhibiting angiogenesis
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Compounds, compositions and methods are provided for modulating the expression of phosphatidylinositol-4-phosphate 5-kinase, type II beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding phosphatidylinositol-4-phosphate 5-kinase, type II beta. Methods of using these compounds for modulation of phosphatidylinositol-4-phosphate 5-kinase, type II beta expression and for diagnosis and treatment of disease associated with expression of phosphatidylinositol-4-phosphate 5-kinase, type II beta are provided.
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- Antisense modulation of phosphoinositide-3-kinase, regulatory subunit 4, p150 expression
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Antisense compounds, compositions and methods are provided for modulating the expression of phosphoinositide-3-kinase, regulatory subunit 4, p150. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding phosphoinositide-3-kinase, regulatory subunit 4, p150. Methods of using these compounds for modulation of phosphoinositide-3-kinase, regulatory subunit 4, p150 expression and for treatment of diseases associated with expression of phosphoinositide-3-kinase, regulatory subunit 4, p150 are provided.
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- Antisense modulation of Rb2/p130 expression
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Antisense compounds, compositions and methods are provided for modulating the expression of Rb2/p130. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Rb2/p130. Methods of using these compounds for modulation of Rb2/p130 expression and for treatment of diseases associated with expression of Rb2/p130 are provided.
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- Antisense modulation of PPP3R1 expression
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Antisense compounds, compositions and methods are provided for modulating the expression of PPP3R1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PPP3R1. Methods of using these compounds for modulation of PPP3R1 expression and for treatment of diseases associated with expression of PPP3R1 are provided.
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- Lithium tetrafluoroborate: A mild and efficient reagent for the cleavage of dimethoxytrityl ethers
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A mild and efficient method for the cleavage of dimethoxytrityl ethers using lithium tetrafluoroborate is reported.
- Chen, Anqi,Zheng, Yong,Zhou, Xinfeng
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p. 3421 - 3423
(2007/10/03)
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- Reactions of some p-Substituted Triphenylmethyl Chlorides with Alcohols, Alkali-metal Alcoholates, and Tributylamine
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The p-methoxylated triphenylmethyl chlorides (4a-c), when heated with alcohols, give mixtures of the corresponding triarylmethanes (5a-c) (via the hydride transfer to the corresponding triarylmethylium cations) and the alkyl (substituted triphenylmethyl) ethers (7a-c) (via polar susbtitution reactions).Part or all of the ether (7c) may be further converted into the substituted triphenylmethanol (6c).In the reaction of the mono-p-methoxylated halides (4a) and (4c) with methanol, the substitution products (7a) and (7c) are formed as the main products, while the main product of the reaction of the di-p-methoxylated halide (4b) with methanol is the substituted triphenylmethane (5b).When the methanol is replaced by 2H4> methanol, no reduction product is formed from the halide (4c).Reaction of halide (4c) with ethanol furnishes exclusively the substituted triphenylmethane (5c).The p-chlorophenyl(diphenyl)methyl chloride (4d) gives, with methanol, mainly or exclusively the ether (7d), and with ethanol, under mild conditions, gives the ether (9d).However, under vigorous conditions, the substituted triphenylmethane (5d) is formed.The reduction of the p-methoxylated triphenylmethyl chloride (4c) by alcohols as well as its conversion into alkyl (p-methoxylated triphenylmethyl) ethers are accompanied, to a certain degree, by exchange of the p-methoxy group of the substrate and the alkoxy group of the alcohol; no similar exchange of the p-chlorine atom of halide (4d) was observed.Explanations for all obsrved diferences are offered.The reactions of the substituted triphenylmethyl chlorides (4b-d) with alkoxides in the corresponding alcohols give the corresponding alkyl (substituted triphenylmethyl) ethers (7b), (7c), (9c), and (9d), respectively, in excellent yields.The reaction of the triarylmethyl chloride (4d) with potassiumt-butoxide in THF in the presence of acetone led, among other products, to the formation of oligomeric material which indicates the operation of single-electron-transfer induced processes.Reaction of the same chloride (4d) with tributylamine in refluxing cumene or t-butylbenzene led to the exclusive formation of a series of products all of which may be derived from the intermediacy of the substituted triphenylmethyl radical (18); the latter, in turn, is thought to arise as a result of dissociative electron transfer from tributylamine to chloride (4d).
- Izso, Gyoengyi,Huszthy, Peter,Lempert, Karoly,Fetter, Jozsef,Simig, Gyula,et al.
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p. 769 - 778
(2007/10/02)
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