- Synthesis method of photoinitiator FMT intermediate
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The invention relates to a synthesis method of a photoinitiator FMT intermediate. The method comprises the following steps: by taking 2, 4-difluoroaniline and furan as raw materials and sulfonated polystyrene microspheres as a catalyst, carrying out sealed heat preservation reaction in a polar solvent, filtering and recovering the catalyst sulfonated polystyrene microspheres, carrying out reducedpressure distillation to recover the solvent and excessive furan to obtain a crude product, crystallizing the crude product by using a non-polar solvent, performing filtering and drying to obtain the2, 4-difluorophenyl pyrrole. The method is simple to operate, the yield can reach more than 90%, the catalyst, the solvent and excessive furan can be recycled, the method is green and environment-friendly, the used materials are industrial products, and are cheaper and easier to obtain, and the quality is easy to control; and the route is a route which is extremely easy to industrialize.
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Paragraph 0029; 0031; 0039-0052
(2020/06/16)
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- A recyclable magnetic nanoparticles supported antimony catalyst for the synthesis of N-substituted pyrroles in water
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A new magnetic nanoparticle-supported antimony catalyst was prepared and evaluated as a recoverable catalyst for Clauson-Kaas reaction. The reaction proceeds efficiently in aqueous medium to give the corresponding N-substituted pyrroles in high yield. The immobilized catalyst could be easily recovered by magnetic separation and recycled for six times without significant loss of its catalytic activity.
- Ma, Fei-Ping,Li, Pei-He,Li, Bao-Le,Mo, Li-Ping,Liu, Ning,Kang, Hui-Jun,Liu, Ya-Nan,Zhang, Zhan-Hui
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- Unique chemoselective Clauson-Kass reaction of substituted aniline catalyzed by MgI2 etherate
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Clauson-Kass reaction of various substituted aniline, primary aryl amide, and sufonyl amide with 2,5-dimethoxytetrahydrofuran was realized in the presence of 10 mol % of MgI2 etherate in a mild, efficient, and highly chemoselective manner. Iodide counterion and solvents (i.e., MeCN) played the critical roles for the unique reactivity of this catalytic system.
- Zhang, Xingxian,Shi, Junchen
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experimental part
p. 898 - 903
(2011/03/19)
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- N-Arylation of nitrogen heterocycles with 2,4-difluoroiodobenzene
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Arylation reactions of NH-heterocycles [specifically, pyrazole, 3-(trifluoromethyl)pyrazole, imidazole and pyrrole] with 2,4-difluoroiodobenzene in the absence and presence of copper catalysis are described. The combination of fluoro and iodo substituents
- Jitchati, Rukkiat,Batsanov, Andrei S.,Bryce, Martin R.
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experimental part
p. 855 - 861
(2009/04/07)
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- Polycondensed heterocycles. VII. A convenient synthesis of pyrrolo[1,2-a]quinoxaline derivatives by intramolecular aromatic nucleophilic displacement
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4-(4-Methyl-1-piperazinyl)-7- trifluoromethylpyrrolo[1,2-a]quinoxaline (CGS 12066B) and related analogs were prepared in good overall yield through a reaction sequence involving as a key step in the intramolecular substitution of aromatic fluoride or nitr
- Campiani,Nacci,Corelli,Anzini
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p. 1567 - 1576
(2007/10/02)
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