125126-63-8

Basic information

• Product Name: 1-(2,4-difluorophenyl)-1H-pyrrole
• Synonyms: 1-(2,4-difluorophenyl)-1H-pyrrole
• CAS NO: 125126-63-8
• Molecular Formula: C₁₀H₇F₂N
• Molecular Weight: 179.1660864
• Mol File: 125126-63-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 225.3°C at 760 mmHg
• Flash Point: 90°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.13mmHg at 25°C
• Refractive Index: 1.529
• PKA: -6.66±0.70(Predicted)
• CAS DataBase Reference: 1-(2,4-difluorophenyl)-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-difluorophenyl)-1H-pyrrole(125126-63-8)
• EPA Substance Registry System: 1-(2,4-difluorophenyl)-1H-pyrrole(125126-63-8)

Safety Data

• Hazardous Substances Data: 125126-63-8(Hazardous Substances Data)

Usage

General Description

1-(2,4-difluorophenyl)-1H-pyrrole is a chemical compound that belongs to the class of pyrrole derivatives. It is a heterocyclic aromatic organic compound that consists of a pyrrole ring substituted with a difluorophenyl group at the 1-position. 1-(2,4-difluorophenyl)-1H-pyrrole has been studied for its potential applications in pharmaceuticals, agrochemicals, and materials science. It exhibits interesting biological activities and has been investigated as a potential candidate for developing new drugs. Additionally, it has shown promising properties for use in the development of new materials. Overall, 1-(2,4-difluorophenyl)-1H-pyrrole is a versatile compound with potential applications in various fields.

InChI:InChI=1/C10H7F2N/c11-8-3-4-10(9(12)7-8)13-5-1-2-6-13/h1-7H

Upstream product

• 110-00-9 furan 
• 367-25-9 2,4-difluorophenylamine 
• 109-97-7 pyrrole 
• 2265-93-2 2,4-difluoro-1-iodobenzene 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 

Downstream Products

• 136773-67-6 7-fluoropyrrolo<1,2-a>quinoxalin-4(5H)-one 
• 136773-69-8 7-fluoro-4-chloropyrrolo[1,2-a]quinoxaline 
• 125126-74-1 1-(2,4-Difluoro-phenyl)-1H-pyrrole-2-carbaldehyde 

Relevant articles and documents

Synthesis method of photoinitiator FMT intermediate

The invention relates to a synthesis method of a photoinitiator FMT intermediate. The method comprises the following steps: by taking 2, 4-difluoroaniline and furan as raw materials and sulfonated polystyrene microspheres as a catalyst, carrying out sealed heat preservation reaction in a polar solvent, filtering and recovering the catalyst sulfonated polystyrene microspheres, carrying out reducedpressure distillation to recover the solvent and excessive furan to obtain a crude product, crystallizing the crude product by using a non-polar solvent, performing filtering and drying to obtain the2, 4-difluorophenyl pyrrole. The method is simple to operate, the yield can reach more than 90%, the catalyst, the solvent and excessive furan can be recycled, the method is green and environment-friendly, the used materials are industrial products, and are cheaper and easier to obtain, and the quality is easy to control; and the route is a route which is extremely easy to industrialize.

Unique chemoselective Clauson-Kass reaction of substituted aniline catalyzed by MgI2 etherate

Clauson-Kass reaction of various substituted aniline, primary aryl amide, and sufonyl amide with 2,5-dimethoxytetrahydrofuran was realized in the presence of 10 mol % of MgI2 etherate in a mild, efficient, and highly chemoselective manner. Iodide counterion and solvents (i.e., MeCN) played the critical roles for the unique reactivity of this catalytic system.

Polycondensed heterocycles. VII. A convenient synthesis of pyrrolo[1,2-a]quinoxaline derivatives by intramolecular aromatic nucleophilic displacement

4-(4-Methyl-1-piperazinyl)-7- trifluoromethylpyrrolo[1,2-a]quinoxaline (CGS 12066B) and related analogs were prepared in good overall yield through a reaction sequence involving as a key step in the intramolecular substitution of aromatic fluoride or nitr