2265-93-2 Usage
Description
2,4-Difluoroiodobenzene is an organic compound characterized by the presence of two fluorine atoms at the 2nd and 4th positions of the benzene ring, with an iodine atom attached at the para position. It is a clear light yellow to slightly brown liquid and is known for its participation in arylation reactions with NH-heterocycles, such as pyrazole, 3-(trifluoromethyl)pyrazole, imidazole, and pyrrole.
Uses
Used in Chemical Synthesis:
2,4-Difluoroiodobenzene is used as a key intermediate in the synthesis of various organic compounds due to its reactivity in arylation reactions with NH-heterocycles. Its ability to form aryl-heterocycle complexes makes it a valuable building block in the development of novel chemical entities.
Used in Pharmaceutical Industry:
2,4-Difluoroiodobenzene is used as a starting material for the preparation of pharmaceutical compounds. For instance, it can be used to synthesize 1,2,4-tris(1H-pyrazolyl)benzene, which is achieved by reacting with pyrazole catalyzed by Cu2O, salicylaldoxime, and Cs2CO3 in acetonitrile. 2,4-Difluoroiodobenzene may have potential applications in the development of new drugs or drug candidates.
Used in the Synthesis of 3-(2,4-difluorophenyl)-2-propyn-1-ol:
2,4-Difluoroiodobenzene is used as a reactant in the preparation of 3-(2,4-difluorophenyl)-2-propyn-1-ol, a compound that may have potential applications in the field of organic chemistry and material science.
Used in the Synthesis of N-(2-((2,4-difluorophenyl)thio)-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)methanesulfonamide:
2,4-Difluoroiodobenzene is also utilized in the synthesis of N-(2-((2,4-difluorophenyl)thio)-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)methanesulfonamide, a complex organic molecule that could be relevant in the development of new pharmaceuticals or chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 2265-93-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,6 and 5 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2265-93:
(6*2)+(5*2)+(4*6)+(3*5)+(2*9)+(1*3)=82
82 % 10 = 2
So 2265-93-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H3F2I/c7-4-1-2-6(9)5(8)3-4/h1-3H
2265-93-2Relevant articles and documents
Metal-free iodination of arylboronic acids and the synthesis of biaryl derivatives
Niu, Liting,Zhang, Hao,Yang, Haijun,Fu, Hua
supporting information, p. 995 - 1000 (2014/05/06)
A simple, general and efficient method is developed for the metal-free iodination of arylboronic acids. The protocol uses very cheap molecular iodine as the halide source and potassium carbonate as the base. The method is highly tolerant of various functional groups present in the substrates. Importantly, the iodination strategy can also be applied very effectively in the one-pot, two-step synthesis of biaryl derivatives. Georg Thieme Verlag Stuttgart New York.
The basicity gradient-driven migration of iodine: Conferring regioflexibility on the substitution of fluoroarenes
Rausis, Thierry,Schlosser, Manfred
, p. 3351 - 3358 (2007/10/03)
Six different fluoroarenes were submitted to the same transformations. Direct deprotonation with alkyllithium or lithium dialkylamide as reagents and subsequent carboxylation afforded the acids 1, 6, 11, 16, 18, and 23. If the aryllithium intermediate was trapped with iodine rather than with dry ice, an iodofluoroarene (2, 7, 12, 17, 19, and 24) was formed. This, upon treatment with lithium diisopropylamide, underwent deprotonation and iodine migration. The resulting new aryllithium species was intercepted either by carboxylation, to give the acids 3, 8, 13, 20, and 25, or by neutralization, to produce the iodofluoroarenes 4, 9, 14, 21, and 26. The latter family of compounds was converted into another set of acids 5, 10, 15, 22, and 27 by subsequent treatment with butyllithium or isopropylmagnesium chloride and carbon dioxide. ( Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).
