- Synthesis of novel biphenyl bis-sulfonamide based surfactants of expected biological activity
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THIS STUDY explores the effect of structural changes of novel sulfonamide based-surfactants on surfactant behavior and antimicrobial activity. In order to better meet this as our primary goal, three different series, biphenyl-4,4′-disulfonamides (Series A, A1-4), amine acid salts of bis (2-aminophenyl) biphenyl-4,4′-disulfonamide (Series B, B 1-4) and their corresponding copper and cobalt complexes (Series C, C1-2) were prepared. The structures of the desired compounds were confirmed by using elemental analysis, Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (1H NMR) and UV-Vis spectral analysis. In addition to these spectroscopic measurements, compounds C1 and C2 (Series C) were subsequently characterized extensively by atomic absorption methods. Also as our secondary goal, we have measured surface properties as follows: surface tension (γ), critical micelle concentration (cmc), the surface excess concentration (Γmax) and the cross-sectional area per adsorbed surfactant head group (Amin). The investigation was continued to cover the antibacterial and antifungal screening for all synthesized compounds. In addition, some selected compounds were screened for cytotoxicity against human tumor cell lines - MCF7 (breast carcinoma), HEPG2 (liver carcinoma) and HCT116 (colon carcinoma).
- Ali, Hanan E. S.,Nassar,Badawi,Afify
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p. 829 - 851
(2013/05/21)
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