- Synthesis of novel biphenyl bis-sulfonamide based surfactants of expected biological activity
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THIS STUDY explores the effect of structural changes of novel sulfonamide based-surfactants on surfactant behavior and antimicrobial activity. In order to better meet this as our primary goal, three different series, biphenyl-4,4′-disulfonamides (Series A, A1-4), amine acid salts of bis (2-aminophenyl) biphenyl-4,4′-disulfonamide (Series B, B 1-4) and their corresponding copper and cobalt complexes (Series C, C1-2) were prepared. The structures of the desired compounds were confirmed by using elemental analysis, Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (1H NMR) and UV-Vis spectral analysis. In addition to these spectroscopic measurements, compounds C1 and C2 (Series C) were subsequently characterized extensively by atomic absorption methods. Also as our secondary goal, we have measured surface properties as follows: surface tension (γ), critical micelle concentration (cmc), the surface excess concentration (Γmax) and the cross-sectional area per adsorbed surfactant head group (Amin). The investigation was continued to cover the antibacterial and antifungal screening for all synthesized compounds. In addition, some selected compounds were screened for cytotoxicity against human tumor cell lines - MCF7 (breast carcinoma), HEPG2 (liver carcinoma) and HCT116 (colon carcinoma).
- Ali, Hanan E. S.,Nassar,Badawi,Afify
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p. 829 - 851
(2013/05/21)
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- POLYMERCAPTOPOLYPHENYLS AND METHOD FOR SYNTHESIS THEREOF
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Novel di-, tri-, or tetra- thiols or thiolates of biphenyl, biphenyl derivatives, terphenyl or terphenyl derivatives, as represented by general formula (A), wherein M1 and M2 are each independently selected from the group consisting of H, Na, Li and K, and R1 to R7 are each H or an organic group, with the proviso that M1, M2 and R1 to R7 may be the same or different from each other; E1 and E2 are SM3 and SM4 (wherein M3 and M4 are each selected from the same group as defined above for M1 or M2) or each a group selected from among those as defined above for R1 to R7; and n is 1 or 0, with the proviso that when n is 0, E1 and E2 are SM3 and SM4.
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- CYCLISATION OF DIARYL COMPOUNDS WITH CHLOROSULFONIC ACID
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Biphenyl (1) and other compounds of type PhXPh (X = O (19); S (30); NH (33); CH2 (40); (CH2)2 (41); (CH2)3 (51); C(CH3)2 (55)) were reacted with chlorosulfonic acid.Under forcing conditions (100-150 deg C), compounds 1, 19, 33, 40, 41, and 55 afforded the cyclic sulfones (2, 26, 27, 39, 43, 46, and 63).Cyclisation occurred most readily with diphenylethane (41) to give the 7-membered sulfone 46).On the other hand, diphenylsulfide (30) and diphenylpropane (51) failed to give cyclic products, while 2,2-diphenylpropane (55) afforded only a low yield of the cyclic compound (63) among a mixture of uncyclised products (57, 61, 62).With chlorosulfonic acid under milder conditions, the substrates afforded mono-, di-, tri- and tetra-sulfonyl chlorides which have been converted into 32 sulfonamides for screening as candidate medicinals and pesticides.The spectroscopic properties of selected compounds are briefly discussed with special reference to the orientation of sulfonation.Key words: Biphenyl; diphenyl compounds (PhXPh, X = O, S, NH, (CH2)n, C(CH3)2); chlorosulfonation.
- Bassin, Jatinder P.,Cremlyn, Richard J.,Lynch, John M.,Swinbourne, Frederic J.
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- Chlorosulfonation of Some Aromatic Compounds
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Dibenzylideneacetone, biphenyl, o-toluanilide, 5-chlorosalicylic acid, and 2,4-, 2,5- and 3,5-dichlorophenol have been reacted with chlorosulfonic acid and the sulfonyl chlorides thus obtained have been characterized by reaction with nucleophilic reagents; in the case of the dichlorophenols the orientation has been confirmed by PMR spectroscopy.The results of preliminary antibacterial and fungicidal screening are included.
- Cremlyn, R. J.,Swinbourne, F. J.,Fitzgerald, P.,Godfrey, N.,Hedges, P.,et al.
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p. 962 - 968
(2007/10/02)
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