A stereoselective intramolecular cyclopropanation via a de novo class of push-pull carbenes derived from DMDO-epoxidations of chiral ynamides
This work describes the first examples of diastereoselective intramolecular cyclopropanations of a de novo class of push-pull carbenes derived from DMDO-epoxidations of chiral ynamides. This reaction sequence essentially constitutes a tandem epoxidation-cyclopropanation that effectively gives rise to a series of structurally unique amido-cyclopropanes. A plausible mechanistic model is proposed revealing insights into this novel cyclopropanation process.
Li, Hongyan,Antoline, Jennifer E.,Yang, Jin-Haek,Al-Rashid, Ziyad F.,Hsung, Richard P.
p. 1309 - 1316
(2010/09/17)
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