- CRBN LIGANDS AND USES THEREOF
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The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
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Paragraph 00527-00529
(2019/08/20)
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- DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES
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A compound having the structure: useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
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Page/Page column 69-70
(2012/05/19)
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- 5-[(1- and 2-naphthalenyl) sulfonyl]-2,4-thiazolidinediones and derivatives thereof
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Disclosed herein are 1- or 2-thio, thiomethylene, and sulfonylnaphthalene derivatives of formulas I and II STR1 or a pharmaceutically acceptable catonic salt thereof, wherein n is 0 or 1 R5 is hydrogen, bromo, chloro, trifluoromethyl or difluoroethyl; R6 is hydrogen, hydroxy, methoxy or ethoxy; and R7 is hydrogen or R7 and R6 are both methyl or ethyl carbonate, provided that, when S(O)2 is in the 2 position of the naphthalene ring, R5, R6 and R7 are each hydrogen. The disclosed compounds possess blood-glucose lowering actions and are useful in the treatment of diabetes mellitus.
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- Synthesis and antihyperglycemia activity of novel 5-(Naphthalenylsulfonyl)-2,4-thiazolidinediones
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A series of 5-(naphthalenylsulfonyl)-2,4-thiazolidinediones were synthesized and evaluated for antihyperglycemic activity in an insulin-resistant, genetically diabetic db/db mouse model of non-insulin-dependent diabetes mellitus (NIDDM). The sulfones coul
- Zask,Jirkovsky,Nowicki,McCaleb
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p. 1418 - 1423
(2007/10/02)
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