125518-48-1

Basic information

• Product Name: 5-Bromothiazolidine-2,4-dione
• Synonyms: 5-Bromothiazolidine-2,4-dione;5-BroMo-2,4-thiazolidinedione;5-Bromo-1,3-Thiazolane-2,4-Dione(WX630018)
• CAS NO: 125518-48-1
• Molecular Formula: C₃H₂BrNO₂S
• Molecular Weight: 196.02248
• Product Categories: Heterocycles;Miscellaneous Reagents;Sulfur & Selenium Compounds;Heterocycles, Miscellaneous Reagents, Sulfur & Selenium Compounds
• Mol File: 125518-48-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Dichloromethane, Methanol
• CAS DataBase Reference: 5-Bromothiazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromothiazolidine-2,4-dione(125518-48-1)
• EPA Substance Registry System: 5-Bromothiazolidine-2,4-dione(125518-48-1)

Safety Data

• Hazardous Substances Data: 125518-48-1(Hazardous Substances Data)

Usage

Description

5-Bromothiazolidine-2,4-dione is a light yellow solid that serves as a key intermediate in the synthesis of various therapeutic Thiazolidine derivatives. These derivatives have demonstrated potential applications in the pharmaceutical industry due to their diverse biological activities.

Uses

Used in Pharmaceutical Industry:
5-Bromothiazolidine-2,4-dione is used as a synthetic intermediate for the development of Thiazolidine derivatives, which possess a range of therapeutic properties. These derivatives are being explored for their potential applications in treating various medical conditions, making 5-Bromothiazolidine-2,4-dione a valuable compound in the pharmaceutical sector.
Used in Chemical Synthesis:
As a light yellow solid, 5-Bromothiazolidine-2,4-dione is also used in chemical synthesis processes to create a variety of compounds with different applications. Its unique chemical properties allow it to be a versatile building block in the development of new materials and products across various industries.

Upstream product

• 2295-31-0 thiazoline-2,4-dione 

Downstream Products

• 125518-79-8 5-(4-fluorophenylsulfanyl)-thiazolidine-2,4-dione 
• 500709-79-5 5-(4-methoxyphenylsulfanyl)-thiazolidine-2,4-dione 
• 391901-61-4 tert-butyl (2 S)-3-(9 H-carbazol-4-yloxy)-2-hydroxypropyl{4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl}carbamate 
• 321575-02-4 tert-butyl (2S)-3-[4-(benzyloxy)phenoxy]-2-hydroxypropyl{4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl}carbamate 
• 391901-76-1 tert-butyl (2 S)-3-(4-butoxyphenoxy)-2-hydroxypropyl{4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl}carbamate 
• 391901-36-3 tert-butyl 4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl[(2 S)-2-hydroxy-3-(4-phenoxyphenoxy)propyl]carbamate 
• 391901-53-4 tert-butyl 4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl[(2 S)-2-hydroxy-3-(4-methoxyphenoxy)propyl]carbamate 
• 391901-58-9 tert-butyl 4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl[(2 S)-2-hydroxy-3-(3-hydroxyphenoxy)propyl]carbamate 
• 391901-49-8 tert-butyl 4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl[(2 S)-3-(4-fluorophenoxy)-2-hydroxypropyl]carbamate 
• 391901-42-1 tert-butyl 4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl[(2 S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]carbamate 

Relevant articles and documents

CRBN LIGANDS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

5-[(1- and 2-naphthalenyl) sulfonyl]-2,4-thiazolidinediones and derivatives thereof

Disclosed herein are 1- or 2-thio, thiomethylene, and sulfonylnaphthalene derivatives of formulas I and II STR1 or a pharmaceutically acceptable catonic salt thereof, wherein n is 0 or 1 R5 is hydrogen, bromo, chloro, trifluoromethyl or difluoroethyl; R6 is hydrogen, hydroxy, methoxy or ethoxy; and R7 is hydrogen or R7 and R6 are both methyl or ethyl carbonate, provided that, when S(O)2 is in the 2 position of the naphthalene ring, R5, R6 and R7 are each hydrogen. The disclosed compounds possess blood-glucose lowering actions and are useful in the treatment of diabetes mellitus.