- CHIRAL DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES
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The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
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Paragraph 0534
(2017/01/23)
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- HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF DISEASES
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The invention relates to compounds of Formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases in which ALK protein is involved or in which inhibition of ALK activity may induce benefit, especially for the treatment of cancer mediated by a mutated EML4-ALK fusion protein.
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