- RENIN INHIBITORS
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Compounds, pharmaceutical compositions, kits, article of manufacture, methods of using, and method of preparing of compounds having the formula of : wherein the variables are as defined herein.
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Page/Page column 22-223
(2008/12/07)
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- Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function
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The present invention is directed to compounds having the formula (I), and/or pharmaceutically-acceptable salts thereof, useful in the treatment of androgen-receptor associated conditions, wherein Ar is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; L is a linker as defined in the specification; R1 may be hydrogen, cyano, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclo, substituted heterocyclo, heteroaryl, or substituted heteroaryl, as defined in the specification; R2 is hydrogen, lower alkyl, or substituted lower alkyl; and R3, R4 and R5 are optionally non-interfering substituents as defined in the specification.
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Page/Page column 19
(2010/11/26)
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- Piperazine compounds
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Compounds are disclosed of formula (I) STR1 wherein R1 represents --COR4, --CO2 R4 or --COCO2 R4 (where R4 represents a hydrogen atom or an unsubstituted or substituted C1-1
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