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127045-41-4

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Pyridonecarboxylic acids as antibacterial agents. IX. Synthesis and structure-activity relationship of 3-substituted 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] -1,4-benzoxazine-6-carboxylic acids and their 1-thio and 1-aza anal
A series of the title compounds listed in Chart 1 have been synthesized to study the effects of 3-alkyl substituents on the antibacterial potency and in vivo efficacy of 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] -1,4-benzoxazi
Todo,Takagi,Iino,Fukuoka,Takahata,Okamoto,Saikawa,Narita
p. 2569 - 2574
(2007/10/02)

Pyridonecarboxylic acids as antibacterial agents. VIII. Synthesis and structure-activity relationship of 7-(1-aminocyclopropyl)-4-oxo-1,8-naphthyridine-3-carboxylic acids and 7-(1-aminocyclopropyl)-4-oxoquinoline-3-carboxylic acids
4-Oxo-1,8-naphthyridine- and 4-oxoquinoline-3-carboxylic acids (2a, b and 3a-l) possessing a 1-aminocyclopropyl group at the 7-position have been synthesized and evaluated for in vitro antibacterial activities. The three quinolones (3d, h, i) exhibited potent antibacterial activities against both gram-positive and gram-negative bacteria, which are comparable to those of ciprofloxacin (CPFX) and ofloxacin (OFLX). Among the three compounds, the best pharmacological and pharmacokinetic profile was obtained with 3i, an OFLX analogue, which was considerably less toxic than three reference quinolones (1, CPFX, and OFLX).
Todo,Nitta,Miyajima,Fukuoka,Yamashiro,Nishida,Saikawa,Narita
p. 2063 - 2070
(2007/10/02)

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More Articles about downstream products of 127045-41-4

127046-18-8
ethyl (S)-9-fluoro-3,7-dihydro-3-methyl-10-(1-aminocyclopropyl)-7-oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate

Chemical Properties

Appearance/Colour :like white to light yellow crystalline
Melting Point: 269-271 °C
Boiling Point: 531.5 °C at 760 mmHg
Flash Point:275.2 °C
Density: 1.56 g/cm³
Solubility:Aqueous Base (Slightly, Sonicated), DMSO (Slightly, Heated), Methanol (Slightly,
Storage Temp.:2-8°C
Vapor Pressure: 4E-12mmHg at 25°C
Refractive Index: 1.692
PKA: 5.05±0.40(Predicted)
PSA: 94.55000
LogP: 2.44030

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