cas 128502-56-7, L-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Articles about 128502-56-7Total 6 be found

Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity
The prominent role of IAPs in controlling cell death and their overexpression in a variety of cancers has prompted the development of IAP antagonists as potential antitumor therapies. We describe the identification of a series of heterodimeric antagonists with highly potent antiproliferative activities in cIAP- and XIAP-dependent cell lines. Compounds 15 and 17 further demonstrate curative efficacy in human melanoma and lung cancer xenograft models and are promising candidates for advanced studies.
Perez, Heidi L.,Chaudhry, Charu,Emanuel, Stuart L.,Fanslau, Caroline,Fargnoli, Joseph,Gan, Jinping,Kim, Kyoung S.,Lei, Ming,Naglich, Joseph G.,Traeger, Sarah C.,Vuppugalla, Ragini,Wei, Donna D.,Vite, Gregory D.,Talbott, Randy L.,Borzilleri, Robert M.
p. 1556 - 1562
(2015)
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A facile synthesis of 1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid, a conformationally constrained tyrosine analogue
A rapid synthesis of 1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid is given. Pictet-Spengler reaction on diiodo- or dibromo-substituted tyrosine (3-(3,5-dihalo-4-hydroxyphenyl)-2-aminopropanoic acid), followed by catalytic dehalogenation gives the desired compound in high optical purity.
Verschueren,Toth,Tourwe,Lebl,Van Binst,Hruby
p. 458 - 460
(1992)
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PROTEOLYSIS-TARGETING CHIMERAS
The present disclosure provides compounds of the formula (I) wherein these compounds contain a ligand which binds to one or more target proteins such as CDK4 or CDK6 and a ligand which binds to the machinery associated with the ubiquitinating protein machinery. Also provided herein are methods of using these compounds in compositions or methods of treating patients with these compounds for the treatment of a disease or disorders such as cancer.
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(2020/05/28)

NOVEL BENZODIAZEPINE DERIVATIVES AND USES THEREOF
The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.
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(2019/12/24)

IAP ANTAGONISTS
There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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(2014/01/09)

Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors
Histone deacetylases (HDACs) are enzymes involved in tumor genesis and development. Herein, we report a novel series of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as HDACs inhibitors. The preliminary biological screening showed that most
Zhang, Yingjie,Feng, Jinhong,Liu, Chunxi,Zhang, Lei,Jiao, Jie,Fang, Hao,Su, Li,Zhang, Xiaopan,Zhang, Jian,Li, Minyong,Wang, Binghe,Xu, Wenfang
experimental part
p. 1761 - 1772
(2010/05/02)