Structure-based design of novel boronic acid-based inhibitors of autotaxin
Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been implicated in inflammation, fibrosis, and tumor progression
Albers, Harald M. H. G.,Hendrickx, Loes J. D.,Van Tol, Rob J. P.,Hausmann, Jens,Perrakis, Anastassis,Ovaa, Huib
p. 4619 - 4626
(2011/09/14)
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