Synthesis and biological evaluation of novel homocamptothecins conjugating with dihydropyrimidine derivatives as potent topoisomerase i inhibitors
Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (-CH2-) spacer between the alcohol moiety and carbonyl group of the classical six-membered α-hydroxylactone ring. This modification provides higher lact