1290616-39-5Relevant articles and documents
Synthesis and biological evaluation of novel homocamptothecins conjugating with dihydropyrimidine derivatives as potent topoisomerase i inhibitors
Zhu, Lingjian,Cheng, Pengfei,Lei, Ning,Yao, Jianzhong,Sheng, Chunquan,Zhuang, Chunlin,Guo, Wei,Liu, Wenfeng,Zhang, Yongqiang,Dong, Guoqiang,Wang, Shengzhang,Miao, Zhenyuan,Zhang, Wannian
, p. 726 - 734 (2012/06/30)
Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (-CH2-) spacer between the alcohol moiety and carbonyl group of the classical six-membered α-hydroxylactone ring. This modification provides higher lact