- PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF
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The present invention relates to an improved process for the preparation of fluvastatin or pharmaceutical acceptable salts or derivatives thereof, in particular to a one-pot process for large scale production of Fluvastatin and salts thereof in high yield
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- A PROCESS FOR THE PREPARATION OF FLUVASTATIN SODIUM
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An efficient and economical process for preparing Fluvastatin sodium of the formula (I) with high purity and in high yield is disclosed. Further a process for preparing Fluva keto alcohol of the formula (II b) and cyclic boronate complex of the formula (I
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Page/Page column 14-15
(2010/11/26)
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- An Improved Manufacturing Process for Fluvastatin
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An improved manufacturing process for fluvastatin 1 has been developed by performing the condensation reaction of E-[3-(4fluorophenyl)-l-(l-methylethyl)- lH-indol-2-yl]-2-propenal, 4, with the dianion of tert-butyl acetoacetate and the subsequent low-temp
- Fuenfschilling, Peter C.,Hoehn, Pascale,Mutz, Jean-Paul
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- PROCESS FOR PREPARATION OF STATINS WITH HIGH SYN TO ANTI RATIO
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Provided is a process for reduction of statin ketoesters and purification of diol esters of the statins through selective crystallization.
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Page/Page column 15
(2008/06/13)
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- PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES BY ENZYMATIC ACYLATION
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A process for the preparation of compounds of formula (1), by enzymatic acylation to form compounds of formulae (3a) and (3a') and then reacting the compound of formula (3a) with a compound introducing the radical of formula -CH2-COOR8
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- Process for the preparation of indole derivatives and intermediates of the process
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A process for the preparation of compounds of formula (1), wherein R1 is C1-C6alkyl and X is hydrogen, a hydrocarbon radical or a cation, wherein a compound of formula (2), wherein R1 is as defined above and Rs
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- Asymmetric synthesis of 3,5-dihydroxy-6(E)-heptenoate-containing HMG-CoA reductase inhibitors
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A 'one-pot' conversion of aldehyde 6 to hydroxyketoester 10 with high enantioselection, culminating in a practical asymmetric synthesis of (3R,5S) isomer of the antihyperlipoproteinemic agent fluvastatin, 1, is described. All four 3,5-dihydroxy-6(E)-heptenoate stereoisomers were prepared in enantiopure form starting from 10, utilizing selective reduction and oxidation methods.
- Tempkin, Orin,Abel, Stephan,Chen, Chung-Pin,Underwood, Russell,Prasad, Kapa,Chen, Kau-Ming,Repic, Oljan,Blacklock, Thomas J.
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p. 10659 - 10670
(2007/10/03)
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