- Transition metal complexes as linkers for solid phase synthesis: Chromium carbonyl complexes as linkers for arenes
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Substrates containing aromatic rings have been attached to 'polymer supported triphenylphosphine' using a chromium carbonyl linker, chemically manipulated, and released from the polymer to demonstrate the potential use π-bound ligands in linker chemistry. Immobilisation of the phenylalanine derivative Fmoc-Phe-OtBu via its aromatic ring has been achieved and the resulting resin successfully subjected to standard amino acid deprotection and coupling procedures.
- Comely,Gibson,Hales,Peplow
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Read Online
- MgI2-Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies
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The scope of MgI2 as a valuable tool for quantitative and mild chemoselective cleavage of protecting groups is described here. This novel synthetic approach expands the use of protecting groups, widens the concept of orthogonality in synthetic processes, and offers a facile opportunity to release compounds from solid supports. Amazing MgI2: Protecting groups have had a tremendous positive impact on the art of biomolecule synthesis. In a context in which the use of attractive protecting groups is often limited by harsh deprotection conditions and low chemoselective flexibility, MgI2 offers, by the execution of a very simple protocol, a fresh vision with extensive perspectives.
- Berthet, Mathéo,Davanier, Florian,Dujardin, Gilles,Martinez, Jean,Parrot, Isabelle
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supporting information
p. 11014 - 11016
(2015/11/10)
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- Versatile selective α-carboxylic acid esterification of N-protected amino acids and peptides by alcalase
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Under continuous removal of water, the industrial protease Alcalase allows selective synthesis of α-carboxylic acid methyl, ethyl, benzyl, allyl, 2-(trimethylsilyl)ethyl, and tert-butyl esters of amino acids and peptides under mild conditions in very high
- Nuijens, Timo,Cusan, Claudia,Kruijtzer, John A. W.,Rijkers, Dirk T. S.,Liskamp, Rob M. J.,Quaedflieg, Peter J. L. M.
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scheme or table
p. 809 - 814
(2009/07/11)
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- Studies directed toward the synthesis of the scabrosins: validation of a tandem enyne metathesis approach
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A synthetic approach to the scabrosin family of antibiotics using a ruthenium carbene-catalyzed tandem metathesis and?a Pd(II)-catalyzed cyclization is described. The chiral propargyl amino acid is furnished through enantioselective phase-transfer proparg
- Middleton, Mark D.,Peppers, Brian P.,Diver, Steven T.
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p. 10528 - 10540
(2007/10/03)
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- A mild and selective method for the cleavage of tert-butyl esters
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A method for the cleavage of t-butyl esters using silica gel in refluxing toluene is reported. Good yields of the corresponding carboxylic acids are obtained, and the reaction is selective for t-butyl esters over t-butyl ethers and trimethylsilylethyl (TMSE) esters.
- Jackson, Randy W
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p. 5163 - 5165
(2007/10/03)
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