129460-18-0Relevant articles and documents
Transition metal complexes as linkers for solid phase synthesis: Chromium carbonyl complexes as linkers for arenes
Comely,Gibson,Hales,Peplow
, p. 2526 - 2531 (2001)
Substrates containing aromatic rings have been attached to 'polymer supported triphenylphosphine' using a chromium carbonyl linker, chemically manipulated, and released from the polymer to demonstrate the potential use π-bound ligands in linker chemistry. Immobilisation of the phenylalanine derivative Fmoc-Phe-OtBu via its aromatic ring has been achieved and the resulting resin successfully subjected to standard amino acid deprotection and coupling procedures.
Versatile selective α-carboxylic acid esterification of N-protected amino acids and peptides by alcalase
Nuijens, Timo,Cusan, Claudia,Kruijtzer, John A. W.,Rijkers, Dirk T. S.,Liskamp, Rob M. J.,Quaedflieg, Peter J. L. M.
scheme or table, p. 809 - 814 (2009/07/11)
Under continuous removal of water, the industrial protease Alcalase allows selective synthesis of α-carboxylic acid methyl, ethyl, benzyl, allyl, 2-(trimethylsilyl)ethyl, and tert-butyl esters of amino acids and peptides under mild conditions in very high
A mild and selective method for the cleavage of tert-butyl esters
Jackson, Randy W
, p. 5163 - 5165 (2007/10/03)
A method for the cleavage of t-butyl esters using silica gel in refluxing toluene is reported. Good yields of the corresponding carboxylic acids are obtained, and the reaction is selective for t-butyl esters over t-butyl ethers and trimethylsilylethyl (TMSE) esters.
