102774-86-7

Basic information

• Product Name: 9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate
• Synonyms: 9H-Fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate
• CAS NO: 102774-86-7
• Molecular Formula: C₁₉H₁₅NO₄
• Molecular Weight: 321.3267
• Mol File: 102774-86-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 495.1°C at 760 mmHg
• Flash Point: 253.2°C
• Density: 1.368g/cm³
• Vapor Pressure: 6.06E-10mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate(102774-86-7)
• EPA Substance Registry System: 9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate(102774-86-7)

Safety Data

• Hazardous Substances Data: 102774-86-7(Hazardous Substances Data)

Usage

General Description

9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate is a chemical compound used as a building block in organic synthesis. It contains a fluorene moiety and a pyrrolidine-2,5-dione ester, making it a versatile molecule for creating various organic compounds. This chemical has the potential to be used in the pharmaceutical industry for creating potential drug candidates due to its structural flexibility and potential for biological activity. Additionally, it can be used in the production of materials such as polymers and dyes due to its unique structure and reactivity. Overall, this chemical compound has a wide range of potential applications in the field of organic chemistry and material science due to its distinctive structure and potential reactivity.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Downstream Products

• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 93372-25-9 4-<(9-fluorenylmethyloxycarbonyl)amino>-4-carboxy-2,2,6,6-tetramethylpiperidine-N-oxyl 
• 185553-38-2 3-{4-[(S)-2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenyl}-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-propionic acid ethyl ester 
• 185553-37-1 3-{4-[(S)-2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenyl}-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-propionic acid tert-butyl ester 
• 115186-31-7 (2R)-2-(tert-butoxycarbonylamino)-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid 
• 350697-60-8 {2,6-bis-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-pyridin-4-yloxy}-acetic acid benzyl ester 
• 575444-10-9 3-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-phenyl]-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionic acid 
• 136590-09-5 (S)-3-(3-nitro-4-hydroxyphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid 
• 652155-94-7 Fmoc-Gly-Tyr(OH)-OBn 
• 302567-98-2 (9H-fluoren-9-yl)methyl (4-methoxyphenyl)carbamate 
• 942233-15-0 C₄₃H₃₃N₃O₆ 
• 718632-80-5 (2'R,4'R)-2'-[(fluoren-9-yl-methoxycarbonyl)aminomethyl]-4'-(N⁶-benzoyladenin-9-yl)-N₁'-(tert-butoxycarbonylmethyl)-pyrrolidine 
• 866641-05-6 ethyl 2-[4-({(2-tert-butoxy-2-oxoethyl)[(9H-fluoren-9-ylmethoxy)carbonyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate 
• 4425-82-5 9-methylene-fluorene 

Relevant articles and documents

Production and cogeneration N [...] succinimide, N '-di-succinimide-based carbon ester method

The invention belongs to the field of fine chemical engineering, and particularly relates to a method for producing fluorenylmethoxycarbonylacyl succinimide and coproducing N,N'-disuccinimidocarbonate. The method comprises the following steps: (1) preparation of Fmoc-cl: adding THF (tetrahydrofuran), 9-fluorenylmethanol and an organic amine catalyst into a reaction kettle, cooling to 0-10 DEG C, adding solid phosgene, and completely reacting; (2) preparation of Fmoc-Osu and DSC: adding Hosu, cooling to -5 to +5 DEG C, dropwisely adding a tributyl amine tetrahydrofuran solution, heating to room temperature, and completely reacting; (3) filtering to obtain a DSC crude product; and (4) carrying out mother solution after-treatment to obtain the Fmoc-Osu. A proper amount of 9-fluorenylmethanol is added into the Hosu/solid phosgene/tributyl amine system to quantitatively generate the two products Fmoc-Osu and DSC, wherein the DSC precipitates in the form of crystalline solid, and the Fmoc-Osu and tributyl amine hydrochloride are still dissolved in the tetrahydrofuran solvent; and therefore, the two products can be respectively subjected to filtration, purification and other routine operations to obtain the refined products with the purity of greater than 99%.