866641-05-6

Basic information

• Product Name: ethyl 2-[4-({(2-tert-butoxy-2-oxoethyl)[(9H-fluoren-9-ylmethoxy)carbonyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate
• Synonyms: ethyl 2-[4-({(2-tert-butoxy-2-oxoethyl)[(9H-fluoren-9-ylmethoxy)carbonyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate
• CAS NO: 866641-05-6
• Molecular Weight: 601.74
• Mol File: 866641-05-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 2-[4-({(2-tert-butoxy-2-oxoethyl)[(9H-fluoren-9-ylmethoxy)carbonyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[4-({(2-tert-butoxy-2-oxoethyl)[(9H-fluoren-9-ylmethoxy)carbonyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate(866641-05-6)
• EPA Substance Registry System: ethyl 2-[4-({(2-tert-butoxy-2-oxoethyl)[(9H-fluoren-9-ylmethoxy)carbonyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate(866641-05-6)

Safety Data

• Hazardous Substances Data: 866641-05-6(Hazardous Substances Data)

Upstream product

• 866640-84-8 ethyl 2-(4-{[(2-tert-butoxy-2-oxoethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate 
• 6456-74-2 Glycine tert-butyl ester 
• 639784-17-1 ethyl 2-(4-formyl-2,6-dimethylphenoxy)-2-methylpropanoate 
• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 866641-06-7 N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycine 
• 1593269-93-2 2-[2,6-dimethyl-4-({[(5-methyl-1,3,4-oxadiazol-2-yl) methyl]-({5-methyl-2-[4-(trifluoromethoxy) phenyl]-1,3-oxazol-4-yl}-methyl) amino}methyl) phenoxy]-2-methylpropanoic acid hydrochloride 
• 1593269-92-1 2-{4-[({[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]-methyl}[(5-methyl-1,3,4-oxadiazol-2-yl) methyl] amino)-methyl]-2,6-dimethylphenoxy}-2-methylpropanoic acid hydrochloride 
• 1593269-91-0 2-{2,6-dimethyl-4-[({[5-methyl-2-(3-methylphenyl)-1,3-oxazol-4-yl] methyl}[(5-methyl-1,3,4-oxadiazol-2-yl) methyl]-amino) methyl] phenoxy}-2-methylpropanoic acid hydrochloride 
• 866641-09-0 ethyl 2-[2,6-dimethyl-4-({[(5-methyl-1,3,4-oxadiazol-2-yl) methyl]amino}methyl)phenoxy]-2-methylpropanoate 
• 866641-08-9 ethyl 2-[4-({[(9H-fluoren-9-ylmethoxy)carbonyl] [(5-methyl-1,3,4-oxadiazol-2-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate 
• 866641-07-8 ethyl 2-[4-({[2-(2-acetylhydrazinyl)-2-oxoethyl][(9Hfluoren-9-ylmethoxy)carbonyl]amino}methyl)-2,6-dimethylphenoxydimethylphenoxy]-2-methylpropanoate 
• 1593269-99-8 C₃₁H₃₅F₃N₄O₆ 
• 1593269-98-7 C₃₁H₃₈N₄O₅ 

Relevant articles and documents

Synthesis and structure-activity relationships of novel zwitterionic compounds as peroxisome proliferator activated receptor α/γ dual agonists with improved physicochemical properties

We describe herein the design, syntheses and structure-activity relationships (SAR) of novel zwitter-ionic compounds as non-thiazolidinedion (TZD) based peroxisome proliferator activated receptor (PPAR) α/γ dual agonists. In the previous report, we obtained compound 1 showing potent PPARα/γ dual agonistic activities, together with a great glucose lowering effect in the db/db mice. However, this compound possessed fatal issues such as potent cytochrome P450 (CYP)3A4 direct inhibitory activity. Thus, we carried out the medicinal optimization to improve these while maintaining the potent PPAR agonistic activity. As a result, the issues were addressed by changing the furan ring to a low lipophilic 1,3,4-oxadiazole ring. Additionally, these oxadiazole derivatives exhibited a significant decrease in plasma glucose and plasma triglyceride levels without marked weight gain.

PYRAZOLE DERIVATIVES

A compound represented by the general formula (I), which is useful as a peroxisome proliferator-activated receptor α/γ agonist, a salt of the compound, and a solvate of either. (In the formula, X, Y, and Z each represents nitrogen or carbon; m is an integ