93372-25-9 Usage
Chemical Properties
Yellow Solid
Uses
Different sources of media describe the Uses of 93372-25-9 differently. You can refer to the following data:
1. A protected spin-labelled, cyclic, chiral ?amino acid resolved in an enantiomerically pure state
2. A stable free radical spin label.
General Description
Fmoc-TOAC-OH is a useful tool for the incorporation of the ESR spin-label TOAC into peptide sequences [1]. Incorporation of this derivative and the following residue is best achieved using HATU activation. TFA/water/TIS should be used for cleavage of TOAC-containing peptides. The use of EDT should be avoided as it can cause permanent reduction of the nitroxide radical [2]. Following cleavage, the TOAC peptide should be treated with aqueous ammonia in air to regenerate the nitroxide from the hydroxylamine that is generated by the TFA treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 93372-25-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,3,7 and 2 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 93372-25:
(7*9)+(6*3)+(5*3)+(4*7)+(3*2)+(2*2)+(1*5)=139
139 % 10 = 9
So 93372-25-9 is a valid CAS Registry Number.
93372-25-9Relevant articles and documents
Orientation of spin labels in de novo peptides
Elsaesser, Celine,Monien, Bernhard,Haehnel, Wolfgang,Bittl, Robert
, p. S26-S33 (2005)
A series of de novo synthesised peptides including the artificial rigid paramagnetic amino acid TOAC at two positions with different distances from two to seven in the primary structure have been investigated by 9- and 94-GHz EPR spectroscopy under solid-state conditions. From simulations of the spectra of such two-spin systems, the distance and relative orientation of the paramagnetic centres can be deduced. This yields structural information on the peptides. A quantitative analysis of the spectra of individual peptides in different solvents as well as a qualitative analysis of the spectra of the peptide series shows that the peptides do not assume conformations corresponding to any of the common helical structures in proteins. Copyright
A novel spin-labeled amino acid derivative for use in peptide synthesis: (9-Fluorenylmethyloxycarbonyl)-2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4- carboxyulic acid
Marchetto, Reinaldo,Schreier, Shirley,Nakaie, Clovis R.
, p. 11042 - 11043 (2007/10/02)
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