15871-56-4 Usage
Description
RAC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4, 4-(5-SPIROHYDANTOIN), also known as rac-2,2,6,6-tetramethylpiperidine-N-oxyl-4,4-(5-spirohydantoin), is a chemical compound with the CAS number 15871-56-4. It is characterized as a yellow solid and is primarily used in the field of organic synthesis.
Uses
Used in Organic Synthesis:
RAC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4, 4-(5-SPIROHYDANTOIN) is used as a synthetic building block for the creation of various organic compounds. Its unique structure and properties make it a valuable component in the synthesis of complex molecules, contributing to the development of new materials and pharmaceuticals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, RAC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4, 4-(5-SPIROHYDANTOIN) is used as an intermediate in the development of new drugs. Its chemical properties allow it to be a key component in the synthesis of potential therapeutic agents, targeting a wide range of medical conditions.
Used in Chemical Research:
RAC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4, 4-(5-SPIROHYDANTOIN) is also utilized in chemical research to study the properties and behavior of various compounds. Its unique structure provides researchers with valuable insights into the reactivity and stability of similar molecules, furthering the understanding of organic chemistry and its applications.
Check Digit Verification of cas no
The CAS Registry Mumber 15871-56-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,8,7 and 1 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 15871-56:
(7*1)+(6*5)+(5*8)+(4*7)+(3*1)+(2*5)+(1*6)=124
124 % 10 = 4
So 15871-56-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H19N3O3/c1-9(2)5-11(6-10(3,4)14(9)17)7(15)12-8(16)13-11/h17H,5-6H2,1-4H3,(H2,12,13,15,16)
15871-56-4Relevant articles and documents
α-helical versus 310-helical conformation of alanine-based peptides in aqueous solution: An electron spin resonance investigation
Smythe, Mark L.,Nakaie, Clovis R.,Marshall, Garland R.
, p. 10555 - 10562 (2007/10/03)
Due to the difficulties in experimentally differentiating between the α- and 310-helical conformations in solution, isolated helical peptides have been assumed to be in the α-helical conformation. However, recent electron spin resonance (ESR) studies have suggested that such peptides, in particular short alanine-based peptides, are 310-helical (Miick, S. M.; et al. Nature 1992, 359, 653-5). This result prompted us to further investigate the helical conformations of alanine-based peptides in solution using electron spin resonance spectroscopy. Unlike previous investigations with a flexible link connecting the spin-label to the peptide backbone, we used a conformationally constrained spin-label (4-amino-4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl, Toac) that is rigidly attached to the peptide backbone. From a combination of molecular modeling and ESR spectroscopy investigations, it was concluded that these alanine-based peptides exist primarily in the α-helical conformation, and not the 310-form as previously suggested for an analogous set of peptides in aqueous environments. This discrepancy is thought to be due to the differences in flexibility of the spin-labels employed. The conformationally constrained spin-label Toac used in this study should accurately reflect the backbone conformation. Free energy surfaces, or potentials of mean force, for the conformational transition of the spin-label used in previous studies (Miick S. M.; et al. Nature 1992, 359, 653-5) suggest that this spin-label is too flexible to accurately distinguish between the α- and 310-helical conformations.
