Role of the Spacer in Conferring κ Opioid Receptor Selectivity to Bivalent Ligands Related to Norbinaltorphimine
The thiophene 2 and pyran 3 analogue of the κ-selective opioid antagonist norbinaltorphimine (1a, norBNI) were synthesized and tested in an effort to determine the contribution of the spacer to the interaction of bivalent ligands at different opioid recep
Portoghese, P. S.,Garzon-Aburbeh, A.,Nagase, H.,Lin, C.-E.,Takemori, A. E.
p. 1292 - 1296
(2007/10/02)
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