129468-29-7Relevant articles and documents
Role of the Spacer in Conferring κ Opioid Receptor Selectivity to Bivalent Ligands Related to Norbinaltorphimine
Portoghese, P. S.,Garzon-Aburbeh, A.,Nagase, H.,Lin, C.-E.,Takemori, A. E.
, p. 1292 - 1296 (2007/10/02)
The thiophene 2 and pyran 3 analogue of the κ-selective opioid antagonist norbinaltorphimine (1a, norBNI) were synthesized and tested in an effort to determine the contribution of the spacer to the interaction of bivalent ligands at different opioid recep
