Synthesis and crystal structure of N,N-BIS[(4-aminophenoxy)ethyl]benzene sulfonamide
The reaction of diethanol amine and benzene sulfonyl chloride produced the benzene sulfonate intermediates, then it was nucleophilicly substituted by 4-nitrophenol and subsequently reduced by hydrazine hydrate in the presence of activated carbon and iron(
Jiang, Guang-Qi,Lu, Yong-Zhong,Cai, Jie
p. 2854 - 2856
(2014/06/09)
PROCESS FOR PREPARATION OF SUBSTANTIALLY OPTICALLY PURE LEVOROTATORY AND DEXTROROTATORY ENANTIOMERS OF CETIRIZINE USING NOVEL INTERMEDIATES
The present invention relates to a novel and commercially viable process for substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine intermediate, 1-[(4-chlorophenyl)phenylmethyl]piperazine, thereby producing substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine and their pharmaceutical acceptable acid addition salts thereof in high purity and in high yield using novel intermediates.
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Page/Page column 2
(2009/12/04)
PROCESS FOR PREPARATION OF SUBSTANTIALLY OPTICALLY PURE LEVOROTATORY AND DEXTROROTATORY ENANTIOMERS OF CETIRIZINE USING NOVEL INTERMEDIATES
The present invention relates to a novel and commercially viable process for substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine intermediate, 1-[(4-chlorophenyl)phenylmethyl]piperazine, thereby producing substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine and their pharmaceutical acceptable acid addition salts thereof in high purity and in high yield using novel intermediates.
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Page/Page column 5-6
(2009/01/24)
Metal oxide in aqueous organic solution promoted chemoselective N-sulfonylation of hydrophilic amino alcohols
The reaction of hydrophilic amino alcohols with sulfonyl chlorides in the presence of metal oxide (MgO, CuO, Ag2O) in aqueous organic solution cleanly provided alkanolsulfonamide. Advantages of this method were mild, neutral reaction conditions
Kang, Hak Hee,Rho, Ho Sik,Kim, Duck Hee,Oh, Seong-Geun
p. 7225 - 7227
(2007/10/03)
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