Direct chemoselective allylation of inert amide carbonyls
Direct allylation of inert amide carbonyls utilizing the Schwartz reagent afforded either substituted tertiary or secondary amines. A preactivation step was successfully avoided, which is generally a requisite to increase the electrophilicity of amides. The reaction exhibited remarkable functional group tolerance and proceeded even in the presence of methyl esters and nitro groups.
Oda, Yukiko,Sato, Takaaki,Chida, Noritaka
supporting information; experimental part
p. 950 - 953
(2012/04/18)
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