- Synthesis and biological properties of 5-(1H-1,2,3-triazol-4-yl)isoxazolidines: A new class of C-nucleosides
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A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases. An antiproliferative effect was observed for compounds 17a and 17b: the growth
- Giofrè, Salvatore V.,Romeo, Roberto,Carnovale, Caterina,Mancuso, Raffaella,Cirmi, Santa,Navarra, Michele,Garozzo, Adriana,Chiacchio, Maria A.
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- Synthesis and evaluation of the cytotoxic activity of Furanaphthoquinones tethered to 1H-1,2,3-triazoles in Caco-2, Calu-3, MDA-MB231 cells
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Naphthoquinones and 1,2,3-triazoles are structural pharmacophore that is known to impart several cancer cells. This work shows a synthetic methodology to obtain hybrid molecules involving naphthoquinone and triazol scaffold as multiple ligands. A simple a
- Costa, Dora C.S.,de Almeida, Gabriella Silva,Rabelo, Vitor Won-Held,Cabral, Lucio Mendes,Sathler, Plínio Cunha,Alvarez Abreu, Paula,Ferreira, Vitor Francisco,Cláudio Rodrigues Pereira da Silva, Luiz,da Silva, Fernando de C.
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p. 524 - 533
(2018/07/25)
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- Synthesis of 4-Vinyl-1H-1,2,3-triazoles on Solid Supports via Polystyrene-Bound But-3-ynyl Selenide
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A facile method for solid-phase organic synthesis of 1-substituted-4-vinyl-1,2,3-triazoles from polystyrene-supported but-3-ynyl selenide has been developed. This sequential [3+2] cycloaddition and oxidation-elimination reactions could be carried out unde
- Ming, Peng,Liu, Xiao-Ling,Wei, Mei-Hong,Sheng, Shou-Ri
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p. 184 - 189
(2016/05/19)
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- Simple synthesis of 1-substituted-4-vinyl-1,2,3-triazoles based on polystyrene-supported sulfonyl chloride
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Polystyrene-supported but-3-ynyl sulfonate reagent has been developed and applied to the traceless solid-phase organic synthesis of 1-substituted-4-vinyl-1,2,3-triazoles by CuI-promoted 1,3-dipolar cycloaddition reaction with various organic azides and su
- Wang, Zhe,Sheng, Shou-Ri,Wei, Mei-Hong,Liu, Xiao-Ling
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p. 226 - 231
(2016/03/09)
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- Synthesis of polymerizable vinyltriazoles: Development of an optimized one-pot strategy starting from 4-bromobutyne
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The development and implementation of a safe and scalable process for the preparation of isomeric vinyl-1,2,3-triazoles under mild conditions are described. Key aspects of the route reside in a one-pot click-elimination procedure in aqueous media leading to simple work-up and purification steps with increased overall yields.
- Praud,Bootzeek,Blache
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supporting information
p. 1138 - 1141
(2013/06/27)
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- Synthesis of 1H-1,2,3-triazoles and study of their antifungal and cytotoxicity activities
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We report herein the results of antifungal activity of fifteen 1,2,3-triazoles against Candida albicans, Candida krusei, Candida parapsilosis, Candida kefyr, Candida tropicalis, Candida dubliniensis, Tricophyton rubrum, Microporum canis and Aspergillus ni
- Da Silva, Iara F.,Martins, Prisicila R.C.,Da Silva, Emanuelly G.,Ferreira, Sabrina B.,Ferreira, Vitor F.,Da Costa, Karen Regina C.,De Vasconcellos, Marne C.,Lima, Emerson S.,Da Silva, Fernando De C.
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p. 1085 - 1090
(2014/01/06)
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- Novel 1,2,3-triazole derivatives for use against mycobacterium tuberculosis H37Rv (ATCC 27294) strain
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The purpose of this study was to prepare various 4-substituted N-phenyl-1,2,3-triazole derivatives using click chemistry. The derivatives were screened in vitro for antimicrobial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 27294) using
- Boechat, Nubia,Ferreira, Vitor F.,Ferreira, Sabrina B.,Ferreira, Maria De Lourdes G.,Da Silva, Fernando De C.,Bastos, Monica M.,Costa, Marilia Dos S.,Louren?o, Maria Cristina S.,Pinto, Angelo C.,Krettli, Antoniana U.,Aguiar, Anna Caroline,Teixeira, Brunno M.,Da Silva, Nathalia V.,Martins, Priscila R. C.,Bezerra, Flavio Augusto F. M.,Camilo, Ane Louise S.,Da Silva, Gerson P.,Costa, Carolina C. P.
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p. 5988 - 5999
(2011/10/09)
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