Debenzylation of functionalized 4- and 5-substituted 1,2,3-triazoles
A range of 4- and 5-substituted N-benzyl-1,2,3-triazoles have been submitted to debenzylation using Pd/C and hydrogen in the presence of 1,1,2-trichloroethane. Triazoles with oxygen-containing substituents are efficiently debenzylated under these conditio
Farooq, Tahir,Sydnes, Leiv K.,Toernroos, Karl W.,Haug, Bengterik
experimental part
p. 2070 - 2078
(2012/08/07)
Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood
Tpl2 (cot/MAP3K8) is an upstream kinase of MEK in the ERK pathway. It plays an important role in Tumor Necrosis Factor-α (TNF-α) production and signaling. We have discovered that 8-halo-4-(3-chloro-4-fluoro-phenylamino)-6-[(1H-[1,2,3]triazol-4-ylmethyl)-a
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor α (TNF-α) production: Selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3- carbonitriles
Tumor progression loci-2 (Tpl2) (Cot/MAP3K8) is a serine/threonine kinase in the MAP3K family directly upstream of MEK. Recent studies using Tpl2 knockout mice have indicated an important role for Tpl2 in the lipopolysaccharide (LPS) induced production of
Green, Neal,Hu, Yonghan,Janz, Kristin,Li, Huan-Qiu,Kaila, Neelu,Guler, Satenig,Thomason, Jennifer,Joseph-McCarthy, Diane,Tam, Steve Y.,Hotchandani, Rajeev,Wu, Junjun,Huang, Adrian,Wang, Qin,Leung, Louis,Pelker, Jefferey,Marusic, Suzana,Hsu, Sang,Telliez, Jean-Baptiste,Hall, J. Perry,Cuozzo, John W.,Lin, Lih-Ling
p. 4728 - 4745
(2008/03/11)
1,3-Dipolar cycloaddition of trimethylsilyl azide to propynals and dimerization of 1H-1,2,3-triazole-5-carbaldehydes to tricyclic bis-hemiaminals
Reactions of trimethylsilyl azide with 3-trimethylsilyl-2-propynal and 2-propynal were studied. X-Ray analysis of the molecular structure of 4-trimethylsilyl-1H-1,2,3-triazole-5-carbaldehyde showed that the carbonyl group appears in the s-cis conformation