- Copper-catalyzed trifluoromethylation of aryl iodides with potassium (trifluoromethyl)trimethoxyborate
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Potassium (trifluoromethyl)trimethoxyborate is introduced as a new source of CF3 nucleophiles in copper-catalyzed trifluoromethylation reactions. The crystalline salt is stable on storage, easy to handle, and can be obtained in near-quantitative yields simply by mixing B(OMe)3, CF3SiMe3, and KF. The trifluoromethylation reagent allows the conversion of various aryl iodides into the corresponding benzotrifluorides in high yields under mild, base-free conditions in the presence of catalytic quantities of a CuI/1,10-phenanthroline complex.
- Knauber, Thomas,Arikan, Fatih,Roeschenthaler, Gerd-Volker,Goossen, Lukas J.
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- Preparation method for 2-cyano-3-fluorobenzotrifluoride
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The invention discloses a preparation method for 2-cyano-3-fluorobenzotrifluoride, in particular to the field of preparation of the 2-cyano-3-fluorobenzotrifluoride. The preparation method specifically comprises the following steps: firstly, reacting 2-fl
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Paragraph 0028; 0038-0041; 0046-0049
(2019/04/17)
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